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Generated Oct 22, 2026
  1. Programmable
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growth playbook · Oct 22, 2026

nuvalent.com (opens in a new tab)

Nuvalent growth playbook

Diagnosis

Nuvalent has an approved ROS1 medicine, a GSK parent and more lung cancer assets behind it, and its hiring is commercial: a Director of JIDEYTRO HCP Marketing to run HCP digital assets, emails, congresses and field training with KPIs, a Medical Affairs strategy director for advisory boards, review and investigator research, and a Thought Leader Liaison for speaker programs and digital opinion leaders.

The digital basics around the launch have gaps: prescribers cannot sign up for updates (patients can), the corporate site routes visitors to a GSK press release rather than the medicine, the rep form is labelled as a patient form, and the brand sites' sitemaps are misdeclared.

This playbook fixes those first, then builds testing education, online speaker programs, access support for office staff, patient support check-ins and a shared HCP platform for future brands, all through the usual medical, legal and regulatory review.

Growth Score

7/10

Biggest Opportunity

Build an owned, consented relationship with the small group of HCPs who treat ROS1-positive NSCLC, and remove the practical barriers between a prescription and the first dose.

Biggest Risk

Several ROS1 therapies compete (AUGTYRO, IBTROZI, Rozlytrek and crizotinib), the population is small, and GSK integration may change systems and plans mid-launch.

01

Start here

The three moves to make first. Each one is written up in full below.

  1. 1

    Let oncologists sign up for JIDEYTRO updates on the HCP site, not only ask for a rep

    Draft the sign-up fields and the first welcome email for PRC review.

    High impact First result in 1 month
  2. 2

    Send nuvalent.com visitors to the medicine, not only to GSK's press release

    Change the banner link to /our-medicines.

    High impact First result in 2 weeks
  3. 3

    Fix the rep request form's label and count every request

    Rename the frame title.

    Medium impact First result in 2 weeks

02

Your idea portfolio

21 ideas, grouped by when to run them. Open any idea for how to run it: the steps, who to approach, copy you can use, and how to measure it.

  • 7 ideas are marked Unexpected: plays you are unlikely to have tried.

Every idea placed by the effort it takes against the impact it could have. Quick wins sit top left; select a number to open that idea. The filters below narrow the list by status, timing, category and what Programmable can build.

Effort vs impactEach number is an idea. Select one to open it.
Impact →
Quick wins · 2Big bets · 8Fill-ins · 6Reconsider · 5
Effort →

Showing 21 of 21 ideas

This week 6

Quick wins with a clear first action.

  • 01

    The new HCP Marketing Director is hired to build digital assets for HCPs, including emails, with KPIs. Yet jideytrohcp.com's only form is a rep request, and the patient site already offers "Stay connected" updates. An oncologist or nurse navigator who reads the data but does not want a rep visit leaves without a way to hear about new resources, dosing materials or access support.

    High impactMedium effort First result in 1 month Director

    First action

    Draft the sign-up fields and the first welcome email for PRC review.

    How to measure it

    Opted-in HCPs

    Now
    –
    Target
    1,500
    By
    2 quarters

    Steps

    1. 1

      Define fields and consent

      Minimum data; privacy and opt-out wording.

      Director, JIDEYTRO HCP Marketing 3 days

    2. 2

      PRC review

      Form copy and welcome series.

      Director, Medical Affairs Strategy 2 weeks

    3. 3

      Build the form

      On home, data and practice resources pages.

      Director, Digital Marketing 1 week

    4. 4

      Connect the CRM

      Sign-ups visible to field teams.

      Commercial Operations 1 week

    5. 5

      Welcome series

      Three approved emails.

      Director, Digital Marketing 2 weeks

    6. 6

      Train the field

      How to use the engagement signal.

      Director, JIDEYTRO HCP Marketing 1 week

    7. 7

      Report

      Sign-ups, opens and resource downloads.

      Insights & Analytics Lead monthly

    First result
    1 month
    Cost
    Email platform and agency time
    Owner
    Director, JIDEYTRO HCP Marketing

    Smallest test

    Add a one-line sign-up on the practice resources page and count sign-ups for a month.

    Why it works

    Add a short, consented HCP sign-up (name, specialty, practice ZIP, NPI optional, topics: clinical data, practice and access resources, congress highlights) on the home, data and practice resources pages. Send a PRC-approved welcome series: the practice resources (EHR order sets, ordering guide), Nuvalent Patient Support and the About ROS1+ NSCLC testing page. Feed sign-ups to the CRM so field teams see engagement.

    Rare-biomarker brands reach few prescribers, so every HCP who self-identifies is worth keeping in touch with. An owned list is also the channel for whatever comes next, at no media cost.

    Ready to use

    ChecklistHCP sign-up launch list

    [ ] Fields: name, specialty, ZIP, NPI optional, topics
    [ ] Consent and opt-out wording approved
    [ ] Form on home, data and practice resources pages
    [ ] Welcome email 1: practice resources and EHR order sets
    [ ] Welcome email 2: Nuvalent Patient Support
    [ ] Welcome email 3: ROS1 testing page
    [ ] CRM sync for field teams
    [ ] Monthly KPI report

    Risks and how to handle them

    • Compliance delays

      Start with already-approved content in the emails.

    • Low volume

      Promote the sign-up in rep emails and at congresses.

    Evidence

    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
    • Your websiteHCP practice resources: EHR instructions for Epic, Oracle Health (Cerner), iKnowMed and OncoEMR, an Ordering Guide and ICD-10 codes. Ordering: "in-office dispensing or Biologics by McKesson, the exclusive specialty pharmacy"; Patient Assistance, Quick Start, Bridge and Copay Assistance programs through Nuvalent Patient Support; template letters of medical necessity, exception and appeal.Source
    • Your websiteHCP site About ROS1+ NSCLC: ROS1 fusions are "found in 1%-2% of people with the disease"; patients "may: Be young, never smokers", "Develop brain metastases"; fusions are detected with DNA-based (FISH, NGS) and RNA-based (PCR, NGS) tests that "can be more accurate when used together", and DNA-based NGS "can miss certain ROS1 fusions".Source
  • 02

    People who search for Nuvalent (oncologists who know it from congresses, patients, pharmacists) land on nuvalent.com. Its "New Approved Therapy" banner goes to a GSK press release, the homepage never links to the JIDEYTRO sites, and /our-medicines, the one page that does, is missing from the sitemap.

    High impactLow effort First result in 2 weeks Director

    First action

    Change the banner link to /our-medicines.

    How to measure it

    Referrals to brand sites

    Now
    –
    Target
    3x
    By
    60 days

    Steps

    1. 1

      Change the banner

      Link to /our-medicines.

      Director, Digital Marketing 1 hour

    2. 2

      Add buttons

      HCP and patient routes on the homepage.

      Director, Digital Marketing 1 day

    3. 3

      Review

      Legal and regulatory check of the buttons.

      Director, Medical Affairs Strategy 1 week

    4. 4

      Fix the sitemap

      Add /our-medicines; drop job links.

      Director, Digital Marketing 1 hour

    5. 5

      Canonical tags

      On all corporate pages.

      Director, Digital Marketing 2 hours

    6. 6

      Track

      Outbound clicks in analytics.

      Insights & Analytics Lead weekly

    First result
    2 weeks
    Cost
    $0
    Owner
    Director, Digital Marketing

    Smallest test

    Change the banner link this week.

    Why it works

    Point the approval banner to /our-medicines, add clear "For US healthcare professionals" and "For US patients" buttons on the homepage, add /our-medicines to the sitemap with a canonical tag, and take the job-link URLs out of the sitemap.

    It turns corporate-site traffic, which spikes with every GSK announcement, into visits to the approved HCP and patient information.

    Risks and how to handle them

    • Corporate site rules under GSK

      Agree the change with GSK communications.

    Evidence

    • Your websitenuvalent.com homepage (checked October 21, 2026): "As of July 15, 2026, GSK has completed the acquisition of Nuvalent. READ MORE" and "New Approved Therapy for Locally Advanced ROS1+ NSCLC! READ MORE" both link to gsk.com press releases. The homepage has no link to the JIDEYTRO patient or HCP sites; the menu item "Our Medicines" is the only route. The page has no canonical tag and no structured data.Source
    • Your websitenuvalent.com sitemap: 15 URLs, including three /jobs?gh_jid= job links, /expanded-access-policy and /our-responsibility, but not /our-medicines. /our-medicines links to the patient site, the HCP site, the Prescribing Information, NuvalentPatientSupport.com and MedInfo, and describes Nuvalent Patient Support as helping "navigate coverage and costs".Source
    • News coverageGSK completed its acquisition of Nuvalent, adding three lung cancer assets: zidesamtinib, neladalkib (under FDA review for ALK-positive NSCLC) and NVL-330 for HER2-altered NSCLC. In May 2026 Nuvalent said "TKI-naïve expansion strategies are underway", its "U.S. commercial and medical affairs teams are in place" for "multiple synergistic launches in biomarker-driven NSCLC", and it appointed a Chief International Officer to lead expansion outside the US.Source
  • 03

    The "Talk to a representative" form on the HCP site is an embedded frame titled "Nuvalent Patient Sign Up". Screen readers announce it as a patient form, and analytics that rely on the frame title may file rep requests as patient sign-ups.

    Medium impactLow effort First result in 2 weeks Director

    First action

    Rename the frame title.

    How to measure it

    Same-day follow-up

    Now
    –
    Target
    90%
    By
    60 days

    Steps

    1. 1

      Rename

      Frame title and heading.

      Director, Digital Marketing 1 hour

    2. 2

      Conversion event

      On submit.

      Director, Digital Marketing 1 day

    3. 3

      Routing

      By territory.

      Commercial Operations 2 days

    4. 4

      SLA

      One business day.

      Regional Sales Director 1 week

    5. 5

      Report

      Requests by page.

      Insights & Analytics Lead weekly

    6. 6

      Review

      Monthly with HCP marketing.

      Director, JIDEYTRO HCP Marketing monthly

    First result
    2 weeks
    Cost
    $0
    Owner
    Director, Digital Marketing

    Smallest test

    Rename the frame today.

    Why it works

    Rename the frame "Request a JIDEYTRO representative", send a conversion event when a request is submitted, report requests by page and source, and route them to the right territory within one business day.

    Rep requests are the clearest sign of HCP intent; they should be measured and answered fast.

    Risks and how to handle them

    • None meaningful

      Test after the change.

    Evidence

    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
  • 04

    The HCP site already offers Epic, Oracle Health, iKnowMed and OncoEMR order-set instructions and an ordering guide. In oncology practices, a drug that is not in the EHR regimen library is slower to prescribe, but these files sit on one page few HCPs will find.

    High impactLow effort First result in 1 month Director

    First action

    Count downloads of each EHR file last month.

    How to measure it

    Practices with JIDEYTRO in their EHR

    Now
    –
    Target
    +50%
    By
    2 quarters

    Steps

    1. 1

      Baseline

      Downloads and known installs.

      Insights & Analytics Lead 1 week

    2. 2

      One-pager

      For pharmacists and informatics.

      Director, JIDEYTRO HCP Marketing 1 week

    3. 3

      PRC review

      Approve the piece.

      Director, Medical Affairs Strategy 2 weeks

    4. 4

      Field rollout

      Reps hand it over.

      Regional Sales Director ongoing

    5. 5

      Email

      In the HCP series.

      Director, Digital Marketing 1 week

    6. 6

      Track

      Installs by practice.

      Commercial Operations monthly

    First result
    1 month
    Cost
    Print and agency time
    Owner
    Director, JIDEYTRO HCP Marketing

    Smallest test

    Give the one-pager to ten target practices.

    Why it works

    Make the EHR resources a field and email priority: a one-page "add JIDEYTRO to your EHR" guide for practice pharmacists and informatics staff, delivered by reps and in the HCP welcome series, with downloads tracked by practice.

    Removing friction at ordering helps prescribing, and practice staff are an audience that brand campaigns rarely reach.

    Risks and how to handle them

    • Practices cannot share install data

      Track downloads and ask in rep calls.

    Evidence

    • Your websiteHCP practice resources: EHR instructions for Epic, Oracle Health (Cerner), iKnowMed and OncoEMR, an Ordering Guide and ICD-10 codes. Ordering: "in-office dispensing or Biologics by McKesson, the exclusive specialty pharmacy"; Patient Assistance, Quick Start, Bridge and Copay Assistance programs through Nuvalent Patient Support; template letters of medical necessity, exception and appeal.Source
    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
  • 05

    Both JIDEYTRO sites list their sitemap in robots.txt at a host other than the live domain, although the live domains already serve working sitemaps. Search engines may ignore the entry or never read the right file, and the setting also reveals details of the build setup that are better kept private.

    Medium impactLow effort First result in 1 week Director

    First action

    Update both robots.txt files.

    How to measure it

    Indexed pages

    Now
    –
    Target
    100% of sitemap
    By
    30 days

    Steps

    1. 1

      Update robots.txt

      Live sitemap URLs.

      Director, Digital Marketing 1 hour

    2. 2

      Review hosts

      Build hosts private.

      IT Security 1 day

    3. 3

      Submit

      Search Console.

      Director, Digital Marketing 1 hour

    4. 4

      Check coverage

      After two weeks.

      Director, Digital Marketing 2 weeks

    5. 5

      Agency checklist

      Add to release steps.

      Director, Digital Marketing 1 day

    6. 6

      Repeat

      For future brand sites.

      Director, Digital Marketing per launch

    First result
    1 week
    Cost
    $0
    Owner
    Director, Digital Marketing

    Smallest test

    Fix the robots.txt files today.

    Why it works

    Change the Sitemap line on both sites to the live /sitemap_index.xml, make sure non-public build hosts are not referenced or reachable publicly, and submit both sitemaps in Search Console.

    Correct sitemaps get updated pages, such as new resources or safety updates, indexed quickly.

    Risks and how to handle them

    • None meaningful

      Check robots.txt after each release.

    Evidence

    • Your websiterobots.txt on both jideytro.com and jideytrohcp.com declares a sitemap on a different, non-public development host rather than the live domain, although the live domains serve working sitemaps (/sitemap_index.xml with page-sitemap.xml).Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
    • Your websitePatient site jideytro.com (14 pages): what ROS1+ NSCLC is, how JIDEYTRO was studied, results, safety and side effects, taking JIDEYTRO, FAQs, patient support, resources, "advocacy-support-groups" and "stay-connected".Source
  • 06

    The HCP Marketing Director must run the tactical plan "with clear budget allocation and KPIs" and "Longitudinally evaluate performance of tactics". Web, email, rep requests, congress and speaker program data usually sit in separate agency reports.

    Medium impactMedium effort First result in 1 month Insights & Analytics Lead

    First action

    List the KPIs per tactic in the plan.

    How to measure it

    Tactics measured

    Now
    –
    Target
    100%
    By
    1 quarter

    Steps

    1. 1

      KPI list

      Per tactic.

      Director, JIDEYTRO HCP Marketing 1 week

    2. 2

      Sources

      Agencies, CRM, web.

      Insights & Analytics Lead 2 weeks

    3. 3

      Dashboard

      Monthly view.

      Insights & Analytics Lead 2 weeks

    4. 4

      Targets

      Per tactic.

      Senior Director, Brand Lead 1 week

    5. 5

      Review

      Monthly.

      Director, JIDEYTRO HCP Marketing monthly

    6. 6

      Reallocate

      Quarterly.

      Senior Director, Brand Lead quarterly

    First result
    1 month
    Cost
    Analytics time
    Owner
    Insights & Analytics Lead

    Smallest test

    Build the first month's view by hand.

    Why it works

    Build one monthly dashboard: HCP site visits by section, resource downloads, sign-ups, rep requests, email engagement, speaker program attendance and field feedback, by territory. Agree targets per tactic.

    Shared numbers let the team move budget to what reaches prescribers.

    Risks and how to handle them

    • Agency data delays

      Make monthly data delivery part of contracts.

    Evidence

    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
    • HiringDirector, National Thought Leader Liaison (remote): engagement "for lung cancer thought leaders, including academic researchers, digital opinion leaders, and other key influencers" as the company prepares launches; identifies promotional speakers and the "brand Speaker Bureau"; supports "KOL videos, Peer to Peer programs, Product theaters"; must be "Proficient in multichannel marketing directed towards HCPs and patients, including digital, media, peer-to-peer, congresses".Source

This quarter 9

The core plays for the next three months.

  • 07

    The HCP site explains that DNA-based NGS "can miss certain ROS1 fusions" and that DNA and RNA tests are more accurate together. ROS1 fusions occur in only 1-2% of NSCLC, so every missed fusion is a patient who may never be offered a ROS1 therapy, whichever brand.

    High impactMedium effort First result in 2 quarters Director

    First action

    Review current testing guidance with Medical.

    How to measure it

    Institutions engaged

    Now
    –
    Target
    200
    By
    3 quarters

    Steps

    1. 1

      Scope

      Medical-led, non-promotional.

      Director, Medical Affairs Strategy 1 month

    2. 2

      Partners

      Medical education providers.

      Director, Medical Affairs Strategy 1 month

    3. 3

      Content

      Testing guides.

      Director, Medical Affairs Strategy 2 months

    4. 4

      MRC review

      Medical Review Committee.

      Director, Medical Affairs Strategy 1 month

    5. 5

      Deliver

      Symposia and webinars.

      Director, Medical Affairs Strategy ongoing

    6. 6

      Measure

      Reach and feedback.

      Insights & Analytics Lead quarterly

    First result
    2 quarters
    Cost
    Medical education grants
    Owner
    Director, Medical Affairs Strategy

    Smallest test

    Run one testing webinar with a molecular pathologist.

    Why it works

    With Medical Affairs leading, create non-promotional education on ROS1 testing (when to add RNA-based testing, how to read reports) for pathologists, molecular labs and oncology nurses, delivered through medical education partners, congress symposia and an unbranded page.

    Better testing grows the identified ROS1 population, which helps patients and every downstream effort.

    Risks and how to handle them

    • Seen as promotional

      Keep it unbranded and Medical-owned.

    Evidence

    • Your websiteHCP site About ROS1+ NSCLC: ROS1 fusions are "found in 1%-2% of people with the disease"; patients "may: Be young, never smokers", "Develop brain metastases"; fusions are detected with DNA-based (FISH, NGS) and RNA-based (PCR, NGS) tests that "can be more accurate when used together", and DNA-based NGS "can miss certain ROS1 fusions".Source
    • HiringDirector, Medical Affairs Strategy (remote): advisory boards, symposia, congress planning and educational initiatives; "a key Medical Affairs contributor on the Promotional Review Committee (PRC) and Medical Review Committee (MRC)"; the Investigator-Sponsored Research (ISR) program; and gathering "scientific and clinical insights from KOL interactions, advisory boards, and scientific conferences".Source
    • News coverageGSK: the FDA approved Jideytro (zidesamtinib) "for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) who received a prior ROS1 kinase inhibitor", ahead of the 18 September 2026 target date, after Breakthrough Therapy and Orphan Drug designations; it is "GSK's first approval in lung cancer". About 50,000 people worldwide are diagnosed with ROS1-positive NSCLC each year, often non-smokers in their 40s and 50s.Source
  • 08

    The Thought Leader Liaison builds the speaker bureau, peer-to-peer programs and congress strategy. Live programs reach the few who attend; community oncologists far from academic centres often cannot.

    High impactMedium effort First result in 1 quarter Director

    First action

    Pick the next speaker program to record.

    How to measure it

    Program attendees

    Now
    –
    Target
    +100%
    By
    2 quarters

    Steps

    1. 1

      Rules

      What can be recorded.

      Legal / Compliance 2 weeks

    2. 2

      Record

      Next programs.

      Director, National Thought Leader Liaison monthly

    3. 3

      Host

      On the HCP site.

      Director, Digital Marketing 1 month

    4. 4

      Virtual sessions

      Evenings.

      Director, National Thought Leader Liaison monthly

    5. 5

      Promote

      Email and reps.

      Director, JIDEYTRO HCP Marketing monthly

    6. 6

      Measure

      Attendance and follow-up.

      Insights & Analytics Lead monthly

    First result
    1 quarter
    Cost
    Production costs
    Owner
    Director, National Thought Leader Liaison

    Smallest test

    Run one virtual evening program.

    Why it works

    Record approved speaker programs and product theaters (where allowed), host them on the HCP site with registration, offer live virtual sessions at evening times, and send highlights to opted-in HCPs.

    Each program reaches many more prescribers for the same speaker and review cost.

    Risks and how to handle them

    • Compliance limits

      Use PRC-approved formats only.

    Evidence

    • HiringDirector, National Thought Leader Liaison (remote): engagement "for lung cancer thought leaders, including academic researchers, digital opinion leaders, and other key influencers" as the company prepares launches; identifies promotional speakers and the "brand Speaker Bureau"; supports "KOL videos, Peer to Peer programs, Product theaters"; must be "Proficient in multichannel marketing directed towards HCPs and patients, including digital, media, peer-to-peer, congresses".Source
    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
  • 09

    The Thought Leader Liaison role explicitly includes "digital opinion leaders" and KOL videos. Oncologists increasingly learn from peers on professional social media and podcasts.

    Medium impactMedium effort First result in 2 quarters Director

    First action

    Map the top 30 lung cancer digital voices.

    How to measure it

    Peer content reach

    Now
    –
    Target
    20,000 HCPs
    By
    2 quarters

    Steps

    1. 1

      Map voices

      Top 30.

      Director, National Thought Leader Liaison 1 month

    2. 2

      Rules

      Contracts and disclosure.

      Legal / Compliance 1 month

    3. 3

      Content

      Approved formats.

      Director, National Thought Leader Liaison 2 months

    4. 4

      Review

      PRC.

      Director, Medical Affairs Strategy ongoing

    5. 5

      Publish

      Channels.

      Director, National Thought Leader Liaison monthly

    6. 6

      Measure

      Reach.

      Insights & Analytics Lead monthly

    First result
    2 quarters
    Cost
    Speaker fees
    Owner
    Director, National Thought Leader Liaison

    Smallest test

    Contract two voices for one approved video each.

    Why it works

    Identify lung cancer clinicians with active professional audiences, engage them under contract for approved content (case-based discussions, testing education via Medical), and track reach. Disclose all paid relationships.

    Peer voices carry more weight than brand messages with specialists.

    Risks and how to handle them

    • Disclosure lapses

      Central approval and monitoring.

    Evidence

    • HiringDirector, National Thought Leader Liaison (remote): engagement "for lung cancer thought leaders, including academic researchers, digital opinion leaders, and other key influencers" as the company prepares launches; identifies promotional speakers and the "brand Speaker Bureau"; supports "KOL videos, Peer to Peer programs, Product theaters"; must be "Proficient in multichannel marketing directed towards HCPs and patients, including digital, media, peer-to-peer, congresses".Source
    • HiringDirector, Medical Affairs Strategy (remote): advisory boards, symposia, congress planning and educational initiatives; "a key Medical Affairs contributor on the Promotional Review Committee (PRC) and Medical Review Committee (MRC)"; the Investigator-Sponsored Research (ISR) program; and gathering "scientific and clinical insights from KOL interactions, advisory boards, and scientific conferences".Source
  • 10

    The HCP site lists Patient Assistance, Quick Start, Bridge and Copay programs, specialty distributors, and letters of medical necessity, exception and appeal. Office staff, not oncologists, do this work, and delays in access can cost patients time on treatment.

    High impactMedium effort First result in 1 quarter Market Access Lead

    First action

    Map the steps from prescription to first dose.

    How to measure it

    Median time to first dose

    Now
    –
    Target
    -20%
    By
    2 quarters

    Steps

    1. 1

      Map the journey

      Prescription to first dose.

      Market Access Lead 2 weeks

    2. 2

      Guide

      One page for office staff.

      Market Access Lead 2 weeks

    3. 3

      Review

      PRC.

      Director, Medical Affairs Strategy 2 weeks

    4. 4

      Train

      Field reimbursement staff.

      Market Access Lead 1 month

    5. 5

      Distribute

      Reps and email.

      Regional Sales Director ongoing

    6. 6

      Measure

      Time to first dose.

      Insights & Analytics Lead monthly

    First result
    1 quarter
    Cost
    Print and training
    Owner
    Market Access Lead

    Smallest test

    Walk five practices through the guide.

    Why it works

    Make a one-page access guide for nurses, financial counsellors and office managers: which program when, how to enroll, the specialty pharmacy path, and the template letters. Train field reimbursement staff to walk practices through it.

    Faster starts and fewer drop-offs are among the biggest levers for a specialty oncology brand.

    Risks and how to handle them

    • Data from the hub is partial

      Track hub-reported starts first.

    Evidence

    • Your websiteHCP practice resources: EHR instructions for Epic, Oracle Health (Cerner), iKnowMed and OncoEMR, an Ordering Guide and ICD-10 codes. Ordering: "in-office dispensing or Biologics by McKesson, the exclusive specialty pharmacy"; Patient Assistance, Quick Start, Bridge and Copay Assistance programs through Nuvalent Patient Support; template letters of medical necessity, exception and appeal.Source
    • Your websitenuvalent.com sitemap: 15 URLs, including three /jobs?gh_jid= job links, /expanded-access-policy and /our-responsibility, but not /our-medicines. /our-medicines links to the patient site, the HCP site, the Prescribing Information, NuvalentPatientSupport.com and MedInfo, and describes Nuvalent Patient Support as helping "navigate coverage and costs".Source
  • 11

    The patient site links to advocacy and support groups, and ROS1+ NSCLC patients are often younger, never smokers, balancing work and family. Patient communities are where newly diagnosed people look first.

    High impactMedium effort First result in 2 quarters Patient Marketing Director

    First action

    Meet the main ROS1 and lung cancer advocacy groups.

    How to measure it

    Patients reached

    Now
    –
    Target
    5,000
    By
    3 quarters

    Steps

    1. 1

      Map groups

      ROS1 and lung cancer.

      Patient Marketing Director 2 weeks

    2. 2

      Listen

      Advisory meetings.

      Patient Marketing Director 1 month

    3. 3

      Grants

      Independent programs.

      Patient Advocacy Lead 1 quarter

    4. 4

      Education

      Co-created, approved.

      Patient Marketing Director 2 months

    5. 5

      Share

      Patient site and groups.

      Director, Digital Marketing ongoing

    6. 6

      Measure

      Reach and feedback.

      Insights & Analytics Lead quarterly

    First result
    2 quarters
    Cost
    Grants
    Owner
    Patient Marketing Director

    Smallest test

    Hold one listening session.

    Why it works

    Work with patient advocacy groups (within compliance rules) on what newly diagnosed patients need: understanding biomarker testing, questions to ask the care team, living with brain metastases. Support their own programs with grants where appropriate.

    Trusted community voices reach patients earlier and help them ask about testing and options.

    Risks and how to handle them

    • Independence concerns

      Keep grants arm's length and disclosed.

    Evidence

    • Your websitePatient site jideytro.com (14 pages): what ROS1+ NSCLC is, how JIDEYTRO was studied, results, safety and side effects, taking JIDEYTRO, FAQs, patient support, resources, "advocacy-support-groups" and "stay-connected".Source
    • Your websitePatient site: the "Stay connected" page also links to advocacy and support groups ("Share your experiences and receive support") and FAQs; the HCP site links "For patients" to jideytro.com.Source
    • Your websiteHCP site About ROS1+ NSCLC: ROS1 fusions are "found in 1%-2% of people with the disease"; patients "may: Be young, never smokers", "Develop brain metastases"; fusions are detected with DNA-based (FISH, NGS) and RNA-based (PCR, NGS) tests that "can be more accurate when used together", and DNA-based NGS "can miss certain ROS1 fusions".Source
    • News coverageGSK: the FDA approved Jideytro (zidesamtinib) "for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) who received a prior ROS1 kinase inhibitor", ahead of the 18 September 2026 target date, after Breakthrough Therapy and Orphan Drug designations; it is "GSK's first approval in lung cancer". About 50,000 people worldwide are diagnosed with ROS1-positive NSCLC each year, often non-smokers in their 40s and 50s.Source
  • 12

    The HCP Marketing Director trains the field force on HCP engagement and runs the Field Sales Advisory Board. After a visit, an HCP often wants the material the rep mentioned.

    Medium impactMedium effort First result in 1 quarter Regional Sales Director

    First action

    Pick the four most requested materials.

    How to measure it

    Visits with follow-up

    Now
    –
    Target
    60%
    By
    2 quarters

    Steps

    1. 1

      Pick content

      Four templates.

      Director, JIDEYTRO HCP Marketing 1 week

    2. 2

      PRC review

      Templates.

      Director, Medical Affairs Strategy 2 weeks

    3. 3

      CRM setup

      Send from CRM.

      Commercial Operations 2 weeks

    4. 4

      Train reps

      When to send.

      Director, JIDEYTRO HCP Marketing 1 week

    5. 5

      Track

      Opens and downloads.

      Insights & Analytics Lead monthly

    6. 6

      Advisory Board

      Review results.

      Director, JIDEYTRO HCP Marketing quarterly

    First result
    1 quarter
    Cost
    CRM configuration
    Owner
    Regional Sales Director

    Smallest test

    Pilot with one region.

    Why it works

    Give reps approved email templates (data summary, dosing, access guide, EHR order sets) to send from the CRM after a visit, and track which ones HCPs open. Feed results to the Advisory Board.

    Timely follow-up reinforces the visit and shows marketing which content field conversations need.

    Risks and how to handle them

    • Off-label risk in free text

      Templates only, no free text.

    Evidence

    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • Your websiteHCP practice resources: EHR instructions for Epic, Oracle Health (Cerner), iKnowMed and OncoEMR, an Ordering Guide and ICD-10 codes. Ordering: "in-office dispensing or Biologics by McKesson, the exclusive specialty pharmacy"; Patient Assistance, Quick Start, Bridge and Copay Assistance programs through Nuvalent Patient Support; template letters of medical necessity, exception and appeal.Source
  • 13

    Medical information requests go by email ([email protected]) or phone from the corporate site. HCPs with unsolicited clinical questions expect a form on the brand's HCP site.

    Medium impactLow effort First result in 1 month Director

    First action

    Define the form fields with Medical Information.

    How to measure it

    On-time answers

    Now
    –
    Target
    95%
    By
    1 quarter

    Steps

    1. 1

      Fields

      With Medical Information.

      Director, Medical Affairs Strategy 1 week

    2. 2

      Build

      Form and routing.

      Director, Digital Marketing 1 week

    3. 3

      Process

      Response targets.

      Director, Medical Affairs Strategy 1 week

    4. 4

      Launch

      HCP site.

      Director, Digital Marketing 1 day

    5. 5

      Themes

      Monthly log.

      Director, Medical Affairs Strategy monthly

    6. 6

      Share

      Insights to brand and medical.

      Director, Medical Affairs Strategy quarterly

    First result
    1 month
    Cost
    $0
    Owner
    Director, Medical Affairs Strategy

    Smallest test

    Launch the form.

    Why it works

    Add a "Request medical information" form to the HCP site, routed to Medical Information with response time targets, and log questions by theme to inform medical strategy.

    Fast, documented answers support appropriate use and feed real questions back to Medical.

    Risks and how to handle them

    • Adverse events in requests

      Route to pharmacovigilance automatically.

    Evidence

    • Your websitenuvalent.com sitemap: 15 URLs, including three /jobs?gh_jid= job links, /expanded-access-policy and /our-responsibility, but not /our-medicines. /our-medicines links to the patient site, the HCP site, the Prescribing Information, NuvalentPatientSupport.com and MedInfo, and describes Nuvalent Patient Support as helping "navigate coverage and costs".Source
    • HiringDirector, Medical Affairs Strategy (remote): advisory boards, symposia, congress planning and educational initiatives; "a key Medical Affairs contributor on the Promotional Review Committee (PRC) and Medical Review Committee (MRC)"; the Investigator-Sponsored Research (ISR) program; and gathering "scientific and clinical insights from KOL interactions, advisory boards, and scientific conferences".Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
  • 14

    HCP Marketing, Medical Affairs and the TLL team all gather insights (advisory boards, KOL interactions, field feedback). Combined, they show what HCPs still need to know.

    Medium impactMedium effort First result in 1 quarter Insights & Analytics Lead

    First action

    Add the feedback prompt to three pages.

    How to measure it

    Gaps closed

    Now
    –
    Target
    5 a quarter
    By
    2 quarters

    Steps

    1. 1

      Prompt

      Three pages.

      Director, Digital Marketing 1 week

    2. 2

      Themes

      Advisory boards and field.

      Insights & Analytics Lead monthly

    3. 3

      Combine

      One list.

      Insights & Analytics Lead monthly

    4. 4

      Prioritise

      Top gaps.

      Director, JIDEYTRO HCP Marketing monthly

    5. 5

      Build

      Approved resources.

      Director, JIDEYTRO HCP Marketing quarterly

    6. 6

      Report

      Closed gaps.

      Insights & Analytics Lead quarterly

    First result
    1 quarter
    Cost
    Staff time only
    Owner
    Insights & Analytics Lead

    Smallest test

    Run the prompt for one month.

    Why it works

    Add a one-question feedback prompt on HCP site pages ("Did this page answer your question?"), combine with advisory board and field themes monthly, and turn top gaps into approved resources.

    Content built from real questions gets used, and the loop gives the tactical plan evidence.

    Risks and how to handle them

    • Off-label questions

      Route clinical questions to Medical Information.

    Evidence

    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • HiringDirector, Medical Affairs Strategy (remote): advisory boards, symposia, congress planning and educational initiatives; "a key Medical Affairs contributor on the Promotional Review Committee (PRC) and Medical Review Committee (MRC)"; the Investigator-Sponsored Research (ISR) program; and gathering "scientific and clinical insights from KOL interactions, advisory boards, and scientific conferences".Source
    • HiringDirector, National Thought Leader Liaison (remote): engagement "for lung cancer thought leaders, including academic researchers, digital opinion leaders, and other key influencers" as the company prepares launches; identifies promotional speakers and the "brand Speaker Bureau"; supports "KOL videos, Peer to Peer programs, Product theaters"; must be "Proficient in multichannel marketing directed towards HCPs and patients, including digital, media, peer-to-peer, congresses".Source
  • 15

    Nuvalent Patient Support says it "supports patients as they start and stay on treatment", and the patient site has a "Stay connected" sign-up. The months after starting are when side effects and practical problems can lead to stopping.

    High impactMedium effort First result in 2 quarters Patient Marketing Director

    First action

    Map the first 90 days of a patient's experience.

    How to measure it

    Enrolled patients using check-ins

    Now
    –
    Target
    50%
    By
    3 quarters

    Steps

    1. 1

      Journey

      First 90 days.

      Patient Marketing Director 1 month

    2. 2

      Design

      Check-ins and reminders.

      Patient Marketing Director 1 month

    3. 3

      Review

      PRC and pharmacovigilance.

      Director, Medical Affairs Strategy 1 month

    4. 4

      Launch

      With Patient Support.

      Patient Marketing Director 1 month

    5. 5

      Feedback

      Patients and HCPs.

      Insights & Analytics Lead quarterly

    6. 6

      Improve

      Quarterly.

      Patient Marketing Director quarterly

    First result
    2 quarters
    Cost
    Program costs
    Owner
    Patient Marketing Director

    Smallest test

    Pilot check-ins for new enrolees in one month.

    Why it works

    With Patient Support, offer enrolled patients scheduled nurse or educator check-ins and approved reminders about what to expect, how to report side effects and when to call the care team.

    Supporting patients through the first months helps them and their care teams manage treatment.

    Risks and how to handle them

    • Medical advice risk

      Educators refer clinical questions to the care team.

    Evidence

    • Your websitenuvalent.com sitemap: 15 URLs, including three /jobs?gh_jid= job links, /expanded-access-policy and /our-responsibility, but not /our-medicines. /our-medicines links to the patient site, the HCP site, the Prescribing Information, NuvalentPatientSupport.com and MedInfo, and describes Nuvalent Patient Support as helping "navigate coverage and costs".Source
    • Your websitePatient site: the "Stay connected" page also links to advocacy and support groups ("Share your experiences and receive support") and FAQs; the HCP site links "For patients" to jideytro.com.Source
    • Your websitePatient site jideytro.com (14 pages): what ROS1+ NSCLC is, how JIDEYTRO was studied, results, safety and side effects, taking JIDEYTRO, FAQs, patient support, resources, "advocacy-support-groups" and "stay-connected".Source

Big bets 3

Larger plays that can change the trajectory.

  • 16

    Nuvalent says it is preparing "multiple synergistic launches in biomarker-driven NSCLC", and GSK now owns three lung cancer assets. Each brand building its own site, list and dashboard repeats work and splits the HCP relationship.

    High impactHigh effort First result in 4 quarters Senior Director

    First action

    Inventory the HCP systems and lists across Nuvalent and GSK.

    How to measure it

    Shared records

    Now
    –
    Target
    100% of opted-in HCPs
    By
    4 quarters

    Steps

    1. 1

      Inventory

      Systems and lists.

      Commercial Operations 1 month

    2. 2

      Consent model

      Per brand and topic.

      Legal / Compliance 2 months

    3. 3

      Platform

      Shared design.

      Director, Digital Marketing 2 quarters

    4. 4

      GSK alignment

      Integration plan.

      Senior Director, Brand Lead 1 quarter

    5. 5

      Migrate

      JIDEYTRO first.

      Director, Digital Marketing 1 quarter

    6. 6

      Measure

      Engagement per HCP.

      Insights & Analytics Lead quarterly

    First result
    4 quarters
    Cost
    Platform costs
    Owner
    Senior Director, Brand Lead

    Smallest test

    Map the overlap of lung cancer HCP targets across assets.

    Why it works

    Design a shared HCP platform: one consent and preference record per HCP (by brand and topic), shared resources for testing and access, and brand-specific sections added only as each is approved. Align with GSK's HCP systems during integration.

    The same oncologists treat ALK, ROS1 and HER2 patients; one relationship is easier for them and cheaper to run.

    Risks and how to handle them

    • Integration changes plans

      Build on systems GSK will keep.

    Evidence

    • News coverageGSK completed its acquisition of Nuvalent, adding three lung cancer assets: zidesamtinib, neladalkib (under FDA review for ALK-positive NSCLC) and NVL-330 for HER2-altered NSCLC. In May 2026 Nuvalent said "TKI-naïve expansion strategies are underway", its "U.S. commercial and medical affairs teams are in place" for "multiple synergistic launches in biomarker-driven NSCLC", and it appointed a Chief International Officer to lead expansion outside the US.Source
    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source
    • Your websitejideytrohcp.com (12 pages in its sitemap): efficacy, intracranial activity, ARROS-1 study design, safety, dosing, About ROS1+ NSCLC, patient support, practice resources and "Talk to a representative". The only HCP form is the rep request, an embedded form whose frame is titled "Nuvalent Patient Sign Up". There is no sign-up for HCP updates, while the patient site jideytro.com has a "Stay connected" page: "Sign up for more information and occasional updates on JIDEYTRO and ROS1+ NSCLC".Source
  • 17

    Nuvalent appointed a Chief International Officer to expand beyond the US, and GSK operates globally. Each market will need local HCP sites, testing education and access programs under its own rules.

    High impactHigh effort First result in 4 quarters Chief International Officer

    First action

    List the modules that are not US-specific.

    How to measure it

    Weeks to local HCP site

    Now
    –
    Target
    -50%
    By
    4 quarters

    Steps

    1. 1

      Modules

      Reusable parts.

      Director, Digital Marketing 1 month

    2. 2

      Templates

      Local language and label.

      Director, Digital Marketing 1 quarter

    3. 3

      Governance

      Local review rules.

      Legal / Compliance 1 quarter

    4. 4

      GSK channels

      Use GSK country teams.

      Chief International Officer 2 quarters

    5. 5

      Pilot

      First approved market.

      Chief International Officer when approved

    6. 6

      Learn

      Update the kit.

      Director, Digital Marketing per market

    First result
    4 quarters
    Cost
    Agency costs
    Owner
    Chief International Officer

    Smallest test

    Build one module (testing education) as a template.

    Why it works

    Turn the US HCP site, access materials and testing education into a modular kit (local language, local label, local access programs) that country teams can adapt once they have approval.

    A tested kit cuts time and cost per country and keeps the science consistent.

    Risks and how to handle them

    • Different rules per market

      Local review before any use.

    Evidence

    • News coverageGSK completed its acquisition of Nuvalent, adding three lung cancer assets: zidesamtinib, neladalkib (under FDA review for ALK-positive NSCLC) and NVL-330 for HER2-altered NSCLC. In May 2026 Nuvalent said "TKI-naïve expansion strategies are underway", its "U.S. commercial and medical affairs teams are in place" for "multiple synergistic launches in biomarker-driven NSCLC", and it appointed a Chief International Officer to lead expansion outside the US.Source
    • News coverageGSK: the FDA approved Jideytro (zidesamtinib) "for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) who received a prior ROS1 kinase inhibitor", ahead of the 18 September 2026 target date, after Breakthrough Therapy and Orphan Drug designations; it is "GSK's first approval in lung cancer". About 50,000 people worldwide are diagnosed with ROS1-positive NSCLC each year, often non-smokers in their 40s and 50s.Source
    • Your websiteHCP practice resources: EHR instructions for Epic, Oracle Health (Cerner), iKnowMed and OncoEMR, an Ordering Guide and ICD-10 codes. Ordering: "in-office dispensing or Biologics by McKesson, the exclusive specialty pharmacy"; Patient Assistance, Quick Start, Bridge and Copay Assistance programs through Nuvalent Patient Support; template letters of medical necessity, exception and appeal.Source
  • 18

    Medical Affairs runs the Investigator-Sponsored Research program and collects HCP questions from advisory boards and congresses. Evidence that answers real practice questions is the most credible content there is.

    Medium impactHigh effort First result in 4 quarters Director

    First action

    Rank the top ten unanswered HCP questions.

    How to measure it

    Aligned ISRs

    Now
    –
    Target
    5
    By
    4 quarters

    Steps

    1. 1

      Questions

      Top ten.

      Director, Medical Affairs Strategy 1 month

    2. 2

      Priorities

      Publish areas.

      Director, Medical Affairs Strategy 1 month

    3. 3

      Review

      Proposals.

      Director, Medical Affairs Strategy ongoing

    4. 4

      Support

      Investigators.

      Director, Medical Affairs Strategy ongoing

    5. 5

      Share

      Congresses.

      Director, Medical Affairs Strategy yearly

    6. 6

      Feed back

      To strategy.

      Director, Medical Affairs Strategy yearly

    First result
    4 quarters
    Cost
    Research grants
    Owner
    Director, Medical Affairs Strategy

    Smallest test

    Publish the ISR priority areas.

    Why it works

    Publish clear ISR priorities based on the top HCP questions (for example sequencing and patients with brain metastases), review proposals against them, and share results at congresses and in publications.

    Independent evidence on practical questions builds lasting trust with prescribers.

    Risks and how to handle them

    • Slow research cycles

      Prioritise feasible studies.

    Evidence

    • HiringDirector, Medical Affairs Strategy (remote): advisory boards, symposia, congress planning and educational initiatives; "a key Medical Affairs contributor on the Promotional Review Committee (PRC) and Medical Review Committee (MRC)"; the Investigator-Sponsored Research (ISR) program; and gathering "scientific and clinical insights from KOL interactions, advisory boards, and scientific conferences".Source
    • Your websiteHCP site About ROS1+ NSCLC: ROS1 fusions are "found in 1%-2% of people with the disease"; patients "may: Be young, never smokers", "Develop brain metastases"; fusions are detected with DNA-based (FISH, NGS) and RNA-based (PCR, NGS) tests that "can be more accurate when used together", and DNA-based NGS "can miss certain ROS1 fusions".Source
    • HiringDirector, National Thought Leader Liaison (remote): engagement "for lung cancer thought leaders, including academic researchers, digital opinion leaders, and other key influencers" as the company prepares launches; identifies promotional speakers and the "brand Speaker Bureau"; supports "KOL videos, Peer to Peer programs, Product theaters"; must be "Proficient in multichannel marketing directed towards HCPs and patients, including digital, media, peer-to-peer, congresses".Source

Wildcards 3

Unexpected experiments, each with a cheap way to test it.

  • 19

    nuvalent.com passes Core Web Vitals for real visitors, but the mobile lab test shows the protein video as the largest element (LCP 3.5 s) and 1.6 s of render-blocking requests. Accessibility flags low contrast and unnamed links.

    Medium impactLow effort First result in 1 month Director

    First action

    Swap the hero video for a poster image on mobile.

    How to measure it

    Mobile LCP (lab)

    Now
    –
    Target
    Under 2.5 s
    By
    1 month

    Steps

    1. 1

      Poster image

      Video after load.

      Director, Digital Marketing 1 day

    2. 2

      Critical CSS

      Inline.

      Director, Digital Marketing 2 days

    3. 3

      Contrast

      Text colours.

      Director, Digital Marketing 1 day

    4. 4

      Link names

      Icon links.

      Director, Digital Marketing 1 day

    5. 5

      Test

      PageSpeed and screen reader.

      Director, Digital Marketing 1 day

    6. 6

      Monitor

      Monthly.

      Director, Digital Marketing monthly

    First result
    1 month
    Cost
    $0
    Owner
    Director, Digital Marketing

    Smallest test

    Add a poster image today.

    Why it works

    Show a still image first and load the video after, inline critical CSS, raise text contrast and name icon links.

    A faster, accessible corporate site helps patients and HCPs on older devices and supports GSK's accessibility standards.

    Risks and how to handle them

    • Design change

      Keep the video, only delay it.

    Evidence

    • Google PageSpeednuvalent.com: real Chrome users see the main content in 1.5 s at the 75th percentile, Interaction to Next Paint 117 ms and layout shift 0.02, so visitors pass Core Web Vitals. The mobile lab score is 82 with LCP 3.5 s; the largest element is a protein rendering video and render-blocking requests cost about 1.6 s. Accessibility flags low-contrast text and links without discernible names.Source
    • Your websitenuvalent.com homepage (checked October 21, 2026): "As of July 15, 2026, GSK has completed the acquisition of Nuvalent. READ MORE" and "New Approved Therapy for Locally Advanced ROS1+ NSCLC! READ MORE" both link to gsk.com press releases. The homepage has no link to the JIDEYTRO patient or HCP sites; the menu item "Our Medicines" is the only route. The page has no canonical tag and no structured data.Source
  • 20

    Nuvalent has a publications page and a strong scientific story (structure-based design, selectivity, brain penetration). Most visitors cannot read posters and abstracts.

    Medium impactLow effort First result in 1 quarter Corporate Communications

    First action

    Write summaries for the five most recent publications.

    How to measure it

    Publication page visits

    Now
    –
    Target
    +50%
    By
    2 quarters

    Steps

    1. 1

      Pick

      Five recent publications.

      Corporate Communications 1 week

    2. 2

      Summaries

      Plain language.

      Corporate Communications 2 weeks

    3. 3

      Review

      Medical and legal.

      Director, Medical Affairs Strategy 2 weeks

    4. 4

      Publish

      Grouped by program.

      Director, Digital Marketing 1 week

    5. 5

      Promote

      LinkedIn.

      Corporate Communications monthly

    6. 6

      Maintain

      Each new publication.

      Corporate Communications ongoing

    First result
    1 quarter
    Cost
    Staff time only
    Owner
    Corporate Communications

    Smallest test

    Summarise one publication.

    Why it works

    Add a short plain-language summary to each publication, group them by program, and link to congress presentations. Keep it non-promotional and reviewed.

    Clear science communication supports recruitment, partnerships and trust during the GSK transition.

    Risks and how to handle them

    • Seen as promotion

      Non-promotional review and no product claims.

    Evidence

    • Your websitenuvalent.com homepage (checked October 21, 2026): "As of July 15, 2026, GSK has completed the acquisition of Nuvalent. READ MORE" and "New Approved Therapy for Locally Advanced ROS1+ NSCLC! READ MORE" both link to gsk.com press releases. The homepage has no link to the JIDEYTRO patient or HCP sites; the menu item "Our Medicines" is the only route. The page has no canonical tag and no structured data.Source
    • News coverageGSK completed its acquisition of Nuvalent, adding three lung cancer assets: zidesamtinib, neladalkib (under FDA review for ALK-positive NSCLC) and NVL-330 for HER2-altered NSCLC. In May 2026 Nuvalent said "TKI-naïve expansion strategies are underway", its "U.S. commercial and medical affairs teams are in place" for "multiple synergistic launches in biomarker-driven NSCLC", and it appointed a Chief International Officer to lead expansion outside the US.Source
  • 21

    The HCP Marketing Director leads the JIDEYTRO Field Sales Advisory Board "to ensure consistent feedback and optimization of promotion materials". Feedback in meetings is often lost.

    Medium impactLow effort First result in 1 quarter Director

    First action

    List all current pieces and their usage.

    How to measure it

    Pieces scored

    Now
    –
    Target
    100%
    By
    2 quarters

    Steps

    1. 1

      List pieces

      All current.

      Director, JIDEYTRO HCP Marketing 1 week

    2. 2

      Scorecard

      Three questions.

      Director, JIDEYTRO HCP Marketing 1 week

    3. 3

      Collect

      Quarterly.

      Regional Sales Director quarterly

    4. 4

      Combine

      With usage data.

      Insights & Analytics Lead quarterly

    5. 5

      Act

      Retire or improve.

      Director, JIDEYTRO HCP Marketing quarterly

    6. 6

      Report

      To brand lead.

      Director, JIDEYTRO HCP Marketing quarterly

    First result
    1 quarter
    Cost
    Staff time only
    Owner
    Director, JIDEYTRO HCP Marketing

    Smallest test

    Score five pieces at the next board meeting.

    Why it works

    Give each piece (visual aid, leave-behinds, emails) a simple quarterly score from the field (used, useful, HCP reaction) alongside usage data, and retire or improve the lowest scorers.

    Materials that reps actually use are the ones HCPs see.

    Risks and how to handle them

    • Survey fatigue

      Keep it to three questions.

    Evidence

    • HiringDirector, JIDEYTRO HCP Marketing (remote, posted October 15, 2026): supports "the company's first LCM indication launch for JIDEYTRO in ROS1+ NSCLC (TKI naïve)" while advancing "the current in-market indication for TKI-pretreated ROS1+ NSCLC"; works "with Digital Marketing on digital assets for HCPs (websites, emails, banners, etc.)"; leads the HCP tactical plan "with clear budget allocation and KPIs", "Peer-to-Peer and Congress strategy", the Core Visual Aid with Medical, Legal and Regulatory review, field sales training and the "JIDEYTRO Field Sales Advisory Board"; and must "Adapt ... as organization navigates GSK integration".Source

03

How Programmable can help

Where an idea in this playbook is something Programmable builds or runs, it's listed here with what we'd do. Everything else is yours to run.

ProgrammableDigital

Show it, don't just describe it

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See every playbook and website review

Independent research. Programmable wrote this playbook from public sources, as they stood on October 22, 2026, and cites them throughout. Nuvalent did not commission, review or endorse it, and Programmable is not affiliated with Nuvalent. Company and product names are trademarks of their owners, used only to identify them. The ideas are suggestions and opinion, not professional, legal or financial advice, and not statements about how Nuvalent runs its business.

Something wrong, or do you represent Nuvalent? Email [email protected] and we will correct it or take it down.

30/60/90 roadmap

What to focus on in each month, and the ideas that carry it.

  1. Days 1 to 306 ideas

    HCP sign-up, corporate-site routing, rep form, EHR order sets, sitemaps and the KPI dashboard.

  2. Days 31 to 6010 ideas

    Testing education, online speaker programs, digital opinion leaders, office-staff access kit, advocacy, rep follow-up, medical information, insights loop and patient check-ins; site speed.

  3. Days 61 to 905 ideas

    Shared HCP platform, international launch kit, ISR priorities, science hub and the materials scorecard.

The research behind the plan

3 research areas, each summarised in a few lines. Open any of them for the full detail.

Customers

What customers say

Customers value A once-daily oral targeted option. The most cited problem: rare biomarker that testing can miss.

  • Practical resources: EHR order sets, ordering guide, access letters
  • Access and coverage steps for specialty drugs
  • In their words: “ROS1-positive”

Market

Competitive landscape

4 competitors compared: AUGTYRO (repotrectinib), IBTROZI (taletrectinib), Rozlytrek (entrectinib) and Crizotinib (Xalkori).

  • Gap to exploit: Better ROS1 testing in community practice
  • AUGTYRO (repotrectinib): Shared focus with NTRK
  • IBTROZI (taletrectinib): Smaller company reach

Hiring signals

Nuvalent is building out JIDEYTRO's commercial engine inside GSK.

  • Director, JIDEYTRO HCP Marketing: HCP websites, emails, congresses, field training and KPIs. Ideas 1, 3, 4, 6, 12, 21.
  • Director, Medical Affairs Strategy: Advisory boards, PRC/MRC review and ISR. Ideas 7, 13, 18.
  • Director, National Thought Leader Liaison: Speaker bureau, KOL videos, digital opinion leaders. Ideas 8, 9.

From the team that wrote this playbook

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