ProgrammableMarketing/bicara.com (opens in a new tab)
PDF

Views

  • Plan
  • Roadmap
  • Research

On this page

  • The brief
  • Start here
  • Idea portfolio
  • Effort vs impact
  • This week · 6
  • This quarter · 10
  • Big bets · 3
  • Wildcards · 3
  • How we can help
Generated Oct 23, 2026
  1. Programmable
  2. Playbooks
  3. Bicara Therapeutics
Bicara Therapeutics logo

growth playbook · Oct 23, 2026

bicara.com (opens in a new tab)

Bicara Therapeutics growth playbook

Diagnosis

Bicara is building a commercial organization (a Chief Commercial Officer, a US Brand Lead, HCP marketing and marketing operations) while its 2026 priority is enrolling FORTIFI-HN01. The digital front door has gaps: the trial recruitment site shows template placeholder contacts in its phone menu and has no referral form, the Spanish page has an English search title, bicara.com delivers its words by script, and real phone visitors wait 3.9 s for the main content.

This playbook fixes trial-site contact and routing first, then builds compliant pre-launch assets: a publication library, an unbranded disease hub, congress follow-up, version control under PMRC and a launch-ready omnichannel stack.

Growth Score

6/10

Biggest Opportunity

Every recruitment visitor who can reach a real person, and every HCP who opts into disease education now, becomes an enrollment or launch audience.

Biggest Risk

Other EGFR-directed first-line programs from Merus and Janssen compete for the same patients, sites and physician attention, and pre-approval communication must stay strictly non-promotional.

01

Start here

The three moves to make first. Each one is written up in full below.

  1. 1

    Replace the placeholder phone and email on the FORTIFI-HN01 trial site, and give patients and doctors one real way to ask

    Swap the placeholder phone and email for the FORTIFI inquiries contact on both pages.

    High impact First result in 1 week
  2. 2

    Translate the Spanish trial page's title and description, so Spanish searches find it

    Write the Spanish title and description.

    Medium impact First result in 1 month
  3. 3

    Make bicara.com's words readable without JavaScript, before the HCP digital launch work begins

    Fetch the five main pages with JavaScript off and list what is missing.

    High impact First result in 1 month

02

Your idea portfolio

22 ideas, grouped by when to run them. Open any idea for how to run it: the steps, who to approach, copy you can use, and how to measure it.

  • 6 ideas are marked Unexpected: plays you are unlikely to have tried.

Every idea placed by the effort it takes against the impact it could have. Quick wins sit top left; select a number to open that idea. The filters below narrow the list by status, timing, category and what Programmable can build.

Effort vs impactEach number is an idea. Select one to open it.
Impact →
Quick wins · 1Big bets · 10Fill-ins · 7Reconsider · 4
Effort →

Showing 22 of 22 ideas

This week 6

Quick wins with a clear first action.

  • 01

    Enrollment is Bicara's 2026 priority, yet on fortificlinicaltrial.com, the recruitment site linked from bicara.com/patients, the "Get in touch" block in the phone and tablet menu still shows the template text "555-555-5555" and "[email removed]", on both the English and Spanish pages. ClinicalTrials.gov lists a real Medical Affairs line and a FORTIFI inquiries address. A patient or caregiver who opens the menu on a phone to ask a question finds a dead end, and there is no referral form for clinicians either.

    High impactLow effort First result in 1 week Senior Clinical Trial Manager

    First action

    Swap the placeholder phone and email for the FORTIFI inquiries contact on both pages.

    How to measure it

    Pre-screened referrals from the trial site

    Now
    –
    Target
    +50%
    By
    90 days

    Steps

    1. 1

      Fix the contact block

      Real phone and FORTIFI inquiries email on /, /es-mx and the menu panel.

      Senior Clinical Trial Manager 1 day

    2. 2

      Audit the template

      Search both pages for any other template text, empty links or test values.

      Web and digital agency 1 day

    3. 3

      Draft the form

      Three pre-screen questions plus zip code; IRB and privacy review.

      Senior Clinical Trial Manager 2 weeks

    4. 4

      Route to centers

      Send each inquiry to the nearest listed site coordinator or a central navigator.

      Clinical Operations lead 1 week

    5. 5

      Add a clinician path

      A referral contact and protocol summary under For Clinicians.

      Senior Medical Science Liaison 1 week

    6. 6

      Track

      Clicks to call, form starts and completions by source and language.

      Director, Marketing Operations 1 week

    7. 7

      Review weekly

      Referrals, screen-fails and site responsiveness.

      Senior Clinical Trial Manager weekly

    First result
    1 week
    Cost
    Agency time and IRB review
    Owner
    Senior Clinical Trial Manager

    Smallest test

    Change the contact block today and count calls and emails for two weeks.

    Why it works

    Put the real FORTIFI inquiries contact (or a trial-navigation service) in the menu block on both language versions, today. Then add a short, IRB-approved "Can I take part?" form that routes to the nearest of the 49 listed US centers, a clinician referral path in the "For Clinicians" section, and click and form tracking so the trial team can see which channel produces pre-screened referrals.

    Recruitment sites are judged by the contacts they produce, and most visitors arrive on phones. Removing a dead end and adding a routed form is the cheapest enrollment gain available, and the marketing operations hire is chartered to keep deployed content approved and current across channels.

    Ready to use

    ChecklistTrial site contact fix list

    [ ] Menu panel phone = real FORTIFI line (English and Spanish)
    [ ] Menu panel email = FORTIFI inquiries address
    [ ] No other template text on either page
    [ ] Spanish page title and description in Spanish
    [ ] Call and email clicks tracked
    [ ] Pre-screen form submitted to IRB
    [ ] Clinician referral contact under For Clinicians

    Risks and how to handle them

    • IRB approval needed for new recruitment wording

      Fix the contact details first (no new claims) and submit the form wording in parallel.

    • Inquiries overwhelm sites

      Use a central navigator to pre-screen before sites are contacted.

    Evidence

    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
    • Trial websiteThe Spanish version (fortificlinicaltrial.com/es-mx) translates the page but keeps the English title "HNSCC Clinical Trial Now Enrolling Near You" and English meta description, and its menu panel shows the same placeholder phone and email.Source
    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
    • HiringDirector, Marketing Operations (posted August 21, 2026): will "Build the marketing operations function from the ground up", chair the Promotional Medical Review Committee (PMRC), set up MLR workflows and KPIs, own the commercial congress calendar, and "Ensure approved content is appropriately deployed, version-controlled, tracked, and retired across channels", including "email marketing, digital advertising, HCP websites, virtual programs".Source
  • 02

    The Spanish version of the trial site translates the page body but keeps the English title and meta description, which are what search results and shared links show. A Spanish-speaking family searching for a head and neck cancer trial sees an English result, if they see it at all.

    Medium impactLow effort First result in 1 month Senior Clinical Trial Manager

    First action

    Write the Spanish title and description.

    How to measure it

    Spanish-page search visits

    Now
    –
    Target
    +100%
    By
    90 days

    Steps

    1. 1

      Translate

      Title and description, reviewed by a native speaker.

      Senior Clinical Trial Manager 1 day

    2. 2

      Add hreflang

      English and Spanish pages point to each other.

      Web and digital agency 1 day

    3. 3

      Sitemap

      List both language pages.

      Web and digital agency 1 hour

    4. 4

      IRB check

      Confirm the translation is covered by approved materials.

      Senior Clinical Trial Manager 1 week

    5. 5

      Share with sites

      Spanish link for coordinators.

      Clinical Operations lead 1 week

    6. 6

      Measure

      Search Console impressions by page.

      Director, Marketing Operations monthly

    First result
    1 month
    Cost
    $0
    Owner
    Senior Clinical Trial Manager

    Smallest test

    Change the title and check Search Console in two weeks.

    Why it works

    Write a Spanish title and description, add hreflang links between the English and Spanish pages, and include the Spanish page in a sitemap. Share the Spanish link with the US centers that serve Spanish-speaking patients.

    Matching the search snippet to the reader's language raises clicks, and the translated page already exists.

    Risks and how to handle them

    • Translation not approved

      Use the already-approved Spanish body text for the snippet.

    Evidence

    • Trial websiteThe Spanish version (fortificlinicaltrial.com/es-mx) translates the page but keeps the English title "HNSCC Clinical Trial Now Enrolling Near You" and English meta description, and its menu panel shows the same placeholder phone and email.Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
  • 03

    Every bicara.com page is drawn by JavaScript from a script variable: a plain fetch of the Patients or Science page returns only the menu as text. Google usually renders scripts, but many AI assistants, link-preview bots and medical search tools read only the delivered HTML, so the trial descriptions and disease education may be invisible to them.

    High impactMedium effort First result in 1 month Director

    First action

    Fetch the five main pages with JavaScript off and list what is missing.

    How to measure it

    Pages readable without JavaScript

    Now
    –
    Target
    100%
    By
    60 days

    Steps

    1. 1

      Audit

      No-JavaScript fetch of every sitemap page.

      Web and digital agency 1 day

    2. 2

      Choose the approach

      Pre-render or server-render the Vue theme.

      Web and digital agency 1 week

    3. 3

      Build

      Main pages first: Patients, Science, About.

      Web and digital agency 2 weeks

    4. 4

      Fix descriptions

      Unique meta description per page.

      Director, Marketing Operations 1 day

    5. 5

      Test previews

      Link previews and an AI assistant query.

      Director, Marketing Operations 1 day

    6. 6

      Monitor

      Indexing and referral traffic.

      Director, Marketing Operations monthly

    First result
    1 month
    Cost
    Agency development time
    Owner
    Director, Marketing Operations

    Smallest test

    Pre-render the Patients page and compare what a no-JavaScript fetch returns.

    Why it works

    Render page content into the HTML on the server (server-side or pre-rendered pages), keep the Vue interactions on top, and give each page its own meta description (the Expanded Access page reuses the homepage's). Test with a no-JavaScript fetch and a link-preview check.

    HCPs and patients increasingly ask AI tools about trials and mechanisms, and the HCP marketing role will run digital and omnichannel programs that point to these pages.

    Risks and how to handle them

    • Theme rebuild cost

      Pre-render as a first step; full rebuild later if needed.

    Evidence

    • Your websitebicara.com is a WordPress site whose page text is delivered inside a script variable and drawn by JavaScript: a plain fetch of /patients/ or /science/ returns only the menu words as page text. The Expanded Access Policy page reuses the homepage meta description. Seven job pages from January to March 2025 (/position/...) are still live and listed in the sitemap, while current roles are on the Ashby board.Source
    • HiringDirector, HCP Marketing (Boston, posted October 16, 2026): leads HCP marketing strategy for ficerafusp alfa "as Bicara prepares for potential US FDA approval"; develops "the HCP launch plan across key channels, including personal promotion, digital/media marketing, peer-to-peer promotions, and congress"; oversees "omnichannel digital and media strategy"; part of "the launch readiness team".Source
    • HiringDirector, Marketing Operations (posted August 21, 2026): will "Build the marketing operations function from the ground up", chair the Promotional Medical Review Committee (PMRC), set up MLR workflows and KPIs, own the commercial congress calendar, and "Ensure approved content is appropriately deployed, version-controlled, tracked, and retired across channels", including "email marketing, digital advertising, HCP websites, virtual programs".Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
  • 04

    Real Chrome visitors fail Core Web Vitals on Largest Contentful Paint (3.9 s at the 75th percentile against a 2.5 s target). In the phone lab test the hero image is the slowest element, and better image delivery would save about 1.1 MB.

    Medium impactLow effort First result in 1 month Web and digital agency

    First action

    Compress and resize the hero image.

    How to measure it

    Field LCP

    Now
    –
    Target
    under 2.5 s
    By
    60 days

    Steps

    1. 1

      Resize images

      Phone and desktop sizes.

      Web and digital agency 1 day

    2. 2

      Modern formats

      WebP or AVIF.

      Web and digital agency 1 day

    3. 3

      Preload the hero

      Priority hint on the LCP image.

      Web and digital agency 1 hour

    4. 4

      Defer blocking files

      Fonts and scripts that block rendering.

      Web and digital agency 2 days

    5. 5

      Retest

      PageSpeed lab test.

      Web and digital agency 1 day

    6. 6

      Check field data

      Chrome UX Report after 28 days.

      Director, Marketing Operations 1 month

    First result
    1 month
    Cost
    Agency time
    Owner
    Web and digital agency

    Smallest test

    Replace only the hero image and retest.

    Why it works

    Serve the hero and page images in WebP or AVIF at phone sizes, preload the hero, and defer render-blocking requests. Recheck PageSpeed and the field data after a month.

    Investors, candidates and HCPs often first see the site on phones from links in emails and posts.

    Risks and how to handle them

    • Visual quality loss

      Compare before and after on retina screens.

    Evidence

    • Google PageSpeedHomepage, mobile lab test: performance 48 (desktop 91), Largest Contentful Paint 10.9 s on the hero image, 2.1 MB page with 1.2 MB of images; estimated savings of 1.1 MB from better image delivery and 1.75 s from render-blocking requests. Real Chrome visitors fail Core Web Vitals on LCP: 3.9 s at the 75th percentile (target 2.5 s); INP 98 ms and CLS 0 pass.Source
  • 05

    Seven /position/ pages from January to March 2025 are still live and in the sitemap, while open roles are on the Ashby board. Candidates who find an old page may apply to roles that no longer exist, and the careers page already warns about recruiting fraud.

    Low impactLow effort First result in 1 week Director

    First action

    List the seven pages and redirect them.

    How to measure it

    Old job pages

    Now
    –
    Target
    0
    By
    2 weeks

    Steps

    1. 1

      List

      Seven pages.

      Director, Marketing Operations 1 hour

    2. 2

      Redirect

      To /careers/.

      Web and digital agency 1 hour

    3. 3

      Sitemap

      Remove the position sitemap.

      Web and digital agency 1 hour

    4. 4

      Link Ashby

      Clear "open roles" link.

      Director, Marketing Operations 1 hour

    5. 5

      Search Console

      Request removal.

      Web and digital agency 1 day

    6. 6

      Process

      Close the page when a role closes.

      Talent Acquisition ongoing

    First result
    1 week
    Cost
    $0
    Owner
    Director, Marketing Operations

    Smallest test

    Redirect one page today.

    Why it works

    Redirect the old position pages to the careers page, drop them from the sitemap, and link the careers page to the live Ashby board.

    A clean careers path helps hiring for the launch team and removes a source of confusion that scammers exploit.

    Risks and how to handle them

    • Lost links

      Redirect rather than delete.

    Evidence

    • Your websitebicara.com is a WordPress site whose page text is delivered inside a script variable and drawn by JavaScript: a plain fetch of /patients/ or /science/ returns only the menu words as page text. The Expanded Access Policy page reuses the homepage meta description. Seven job pages from January to March 2025 (/position/...) are still live and listed in the sitemap, while current roles are on the Ashby board.Source
    • Your websiteCareers page: values ("Patient Driven, Highly Adaptive, Openly Candid") and a warning that "All formal communication regarding job opportunities at Bicara will come exclusively from an official @bicara.com email address"; the About page announces leadership transitions effective January 1, 2027.Source
  • 06

    FORTIFI-FLEX is recruiting and described on bicara.com/patients, but the recruitment site only covers FORTIFI-HN01. Patients who do not fit one study, or live near a center running the other, have no path.

    Medium impactLow effort First result in 1 month Senior Clinical Trial Manager

    First action

    Draft the FLEX section from approved wording on bicara.com/patients.

    How to measure it

    FLEX inquiries from the site

    Now
    –
    Target
    20 a month
    By
    90 days

    Steps

    1. 1

      Draft

      From approved study descriptions.

      Senior Clinical Trial Manager 2 days

    2. 2

      Locations

      FLEX centers by state.

      Clinical Operations lead 2 days

    3. 3

      IRB review

      Recruitment wording.

      Senior Clinical Trial Manager 2 weeks

    4. 4

      Publish

      English and Spanish.

      Web and digital agency 1 day

    5. 5

      Route

      Same form, study tag.

      Clinical Operations lead 1 day

    6. 6

      Measure

      Inquiries by study.

      Director, Marketing Operations monthly

    First result
    1 month
    Cost
    Agency time and IRB review
    Owner
    Senior Clinical Trial Manager

    Smallest test

    Add a one-paragraph FLEX note with the registry link.

    Why it works

    Add a short FLEX section with eligibility basics, locations and the ClinicalTrials.gov link, and a "which study might fit me" note that routes to the same inquiry form.

    One trusted recruitment address serves more patients and gives referring doctors one link to remember.

    Risks and how to handle them

    • Confusing two studies

      Keep each section short with a clear contact.

    Evidence

    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source

This quarter 10

The core plays for the next three months.

  • 07

    Many patients are diagnosed and treated in community practices, while the 49 listed US study centers are mainly large cancer centers. MSLs build relationships with investigators and institutions and answer unsolicited requests; a structured referral program connects the two.

    High impactMedium effort First result in 1 quarter Senior Medical Science Liaison

    First action

    Map practices around the five centers with the most screening capacity.

    How to measure it

    Community referrals

    Now
    –
    Target
    +30%
    By
    2 quarters

    Steps

    1. 1

      Map practices

      Within 100 miles of each center.

      Insights & Analytics 2 weeks

    2. 2

      Build materials

      Protocol summary and referral contact, MLR approved.

      Associate Director, Global Scientific Communications 1 month

    3. 3

      Train MSLs

      Compliant scientific exchange only.

      Head of Medical Affairs 2 weeks

    4. 4

      Launch

      West territory first.

      Senior Medical Science Liaison 1 quarter

    5. 5

      Feedback

      Site coordinators report outcomes.

      Clinical Operations lead monthly

    6. 6

      Review

      Referrals and screen-fails by practice.

      Senior Clinical Trial Manager monthly

    First result
    1 quarter
    Cost
    Field time
    Owner
    Senior Medical Science Liaison

    Smallest test

    Run it around one center for a month.

    Why it works

    Map community oncology and ENT practices within driving distance of each center, give MSLs a compliant protocol summary and referral contact to share on request, and track referrals and screen outcomes by practice.

    Referrals from the doctors who see patients first are the steadiest source of enrollment.

    Risks and how to handle them

    • Promotional concerns

      Medical affairs owns it; no product claims.

    Evidence

    • HiringSenior Medical Science Liaison - West (CA, WA), posted August 17, 2026: "fair and balanced education on investigational products", relationships with investigators and institutions, the investigator-initiated research program, and "responses to unsolicited requests for medical information"; plus a Senior Clinical Trial Manager (posted September 17, 2026).Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
  • 08

    bicara.com lists 27 presentations and publications as separate pages with very long titles, and the scientific communications role is hired to build "digital publication extenders" and interactive tools. Today a doctor cannot filter by congress, study or year.

    High impactMedium effort First result in 1 quarter Associate Director

    First action

    Tag the 27 items by congress, year and study.

    How to measure it

    Monthly library downloads

    Now
    –
    Target
    1,000
    By
    2 quarters

    Steps

    1. 1

      Tag items

      Congress, year, study, tumor.

      Associate Director, Global Scientific Communications 1 week

    2. 2

      Design

      Filterable list.

      Web and digital agency 2 weeks

    3. 3

      Summaries

      One line each, MLR reviewed.

      Associate Director, Global Scientific Communications 1 month

    4. 4

      Build

      Library page.

      Web and digital agency 1 month

    5. 5

      Process

      New items added at each congress.

      Associate Director, Global Scientific Communications ongoing

    6. 6

      Measure

      Downloads by item.

      Director, Marketing Operations monthly

    First result
    1 quarter
    Cost
    Agency time
    Owner
    Associate Director, Global Scientific Communications

    Smallest test

    Group the items by congress on one page.

    Why it works

    Build a publication library with filters (congress, year, study, tumor type), one-line plain summaries, the PDF and the citation, and a plain-language summary where allowed. Keep it under medical affairs, with no promotional framing.

    It makes the evidence easy to find for HCPs and journalists and becomes the home for each new congress release.

    Risks and how to handle them

    • Promotional appearance

      Medical review owns the library.

    Evidence

    • Your websiteSitemap (80 URLs): 27 presentations and publications (ASCO 2023 to ASCO 2026, ESMO, SITC, a 2026 Journal of Clinical Oncology paper), each a separate page with a long title; 31 team pages; no HCP-specific section, no disease-awareness hub beyond the Patients page, and no news posts on the site (press releases live on ir.bicara.com).Source
    • HiringAssociate Director, Global Scientific Communications (posted July 6, 2026, still open): runs the global publication plan (manuscripts, abstracts, posters and "digital publication extenders"), pulls the Scientific Communication Platform into all deliverables, and builds slide decks, FAQs and "interactive educational tools" for field medical teams, under GPP2022 and ICMJE rules.Source
  • 09

    The HCP marketing lead is building the launch plan and digital mix before potential approval. Before approval, a company can run disease-state education. Bicara's own patient page already explains that an estimated 80% of R/M HNSCC is HPV-negative and why that matters.

    High impactMedium effort First result in 1 quarter Director

    First action

    Pick five topics with MLR.

    How to measure it

    HCP registrations

    Now
    –
    Target
    2,000
    By
    3 quarters

    Steps

    1. 1

      Pick topics

      Five disease topics.

      Director, HCP Marketing 2 weeks

    2. 2

      MLR plan

      Unbranded rules.

      Legal & Compliance (PMRC) 2 weeks

    3. 3

      Write

      Content with KOL review.

      Director, HCP Marketing 1 month

    4. 4

      Build

      Hub and opt-in.

      Web and digital agency 1 month

    5. 5

      Promote

      HCP media and congresses.

      Director, HCP Marketing 1 quarter

    6. 6

      Measure

      Registrations and engagement.

      Director, Marketing Operations monthly

    First result
    1 quarter
    Cost
    Content and media budget
    Owner
    Director, HCP Marketing

    Smallest test

    Publish one disease topic page.

    Why it works

    Build an unbranded disease hub for oncologists: HPV status testing, PD-L1 scoring, patterns of recurrence and current guidelines, with downloadable tools. Use it to build an opted-in HCP audience and test messages.

    It gives the launch team a compliant audience, data on what HCPs care about, and a channel ready for launch.

    Risks and how to handle them

    • Seen as pre-approval promotion

      Strictly unbranded content with no product mention, reviewed by PMRC.

    Evidence

    • HiringDirector, HCP Marketing (Boston, posted October 16, 2026): leads HCP marketing strategy for ficerafusp alfa "as Bicara prepares for potential US FDA approval"; develops "the HCP launch plan across key channels, including personal promotion, digital/media marketing, peer-to-peer promotions, and congress"; oversees "omnichannel digital and media strategy"; part of "the launch readiness team".Source
    • HiringSenior Director, Brand Lead - US (posted September 25, 2026): the "day-to-day brand owner" who builds the integrated brand plan "across HCP, patient, digital, field, and other customer channels", leads message testing, segmentation and customer journey research, "Day 0 planning", and engagement for "medical oncologists, academic and community oncology practices".Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
  • 10

    The marketing operations role must ensure approved content is "deployed, version-controlled, tracked, and retired across channels", including HCP websites. The placeholder contact text on the trial site shows that live pages can drift outside review.

    High impactMedium effort First result in 1 quarter Director

    First action

    List every public URL and PDF.

    How to measure it

    Assets with approval records

    Now
    –
    Target
    100%
    By
    1 quarter

    Steps

    1. 1

      Inventory

      Every URL and PDF.

      Director, Marketing Operations 2 weeks

    2. 2

      Record

      Owner, approval, expiry.

      Director, Marketing Operations 2 weeks

    3. 3

      Choose a tool

      Promotional review system.

      Director, Marketing Operations 1 month

    4. 4

      Live check

      Compare live with approved.

      Web and digital agency quarterly

    5. 5

      Retire

      Expired assets removed.

      Director, Marketing Operations ongoing

    6. 6

      Report

      KPIs to PMRC.

      Legal & Compliance (PMRC) quarterly

    First result
    1 quarter
    Cost
    Review tool licence
    Owner
    Director, Marketing Operations

    Smallest test

    Inventory the trial site and patient PDFs first.

    Why it works

    Build a register of every public asset (bicara.com, the trial site, PDFs, congress pages), with owner, approval number, review date and expiry. Add a quarterly live-page check against approved versions.

    Launch multiplies assets; a register built now prevents off-label or outdated content going live later.

    Risks and how to handle them

    • Extra process slows teams

      Keep the register light.

    Evidence

    • HiringDirector, Marketing Operations (posted August 21, 2026): will "Build the marketing operations function from the ground up", chair the Promotional Medical Review Committee (PMRC), set up MLR workflows and KPIs, own the commercial congress calendar, and "Ensure approved content is appropriately deployed, version-controlled, tracked, and retired across channels", including "email marketing, digital advertising, HCP websites, virtual programs".Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
  • 11

    FORTIFI-HN01 lists 231 sites in 28 countries, 176 of them outside the US (20 in Brazil, 18 in Italy), but the recruitment site says "For US audiences only". Patients and doctors outside the US land on ClinicalTrials.gov alone.

    High impactHigh effort First result in 2 quarters Senior Clinical Trial Manager

    First action

    Rank countries by sites and screening gaps.

    How to measure it

    Non-US inquiries

    Now
    –
    Target
    100 a month
    By
    2 quarters

    Steps

    1. 1

      Rank countries

      Sites and enrollment gaps.

      Clinical Operations lead 1 week

    2. 2

      Draft

      From the approved core.

      Senior Clinical Trial Manager 1 month

    3. 3

      Ethics approval

      Country by country.

      Senior Clinical Trial Manager 1 quarter

    4. 4

      Translate

      Native medical translators.

      Senior Clinical Trial Manager 1 month

    5. 5

      Publish

      One country at a time.

      Web and digital agency ongoing

    6. 6

      Measure

      Inquiries by country.

      Director, Marketing Operations monthly

    First result
    2 quarters
    Cost
    Translation and ethics fees
    Owner
    Senior Clinical Trial Manager

    Smallest test

    Launch one country page.

    Why it works

    Build simple country pages in local languages for the largest countries (Brazil, Italy, Germany, the UK, France, Spain), each approved by local ethics committees, with site lists and contacts.

    Most sites are outside the US, and local-language pages help referring doctors and families act.

    Risks and how to handle them

    • Country rules differ

      Use local CRO partners for approvals.

    Evidence

    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
  • 12

    Bicara's guides already point to nonprofit organizations, and the trial site links two head and neck cancer groups. Advocacy groups reach patients and caregivers at diagnosis and recurrence.

    Medium impactMedium effort First result in 1 quarter Patient Advocacy lead

    First action

    Meet two advocacy groups.

    How to measure it

    Visits from advocacy links

    Now
    –
    Target
    500 a month
    By
    2 quarters

    Steps

    1. 1

      List groups

      US and global.

      Patient Advocacy lead 1 week

    2. 2

      Meet

      Two groups.

      Patient Advocacy lead 1 month

    3. 3

      Grant terms

      Independent content.

      Legal & Compliance (PMRC) 1 month

    4. 4

      Webinars

      Twice a year.

      Patient Advocacy lead 2 quarters

    5. 5

      Trial finder

      Neutral resource.

      Patient Advocacy lead 1 quarter

    6. 6

      Measure

      Referral visits.

      Director, Marketing Operations monthly

    First result
    1 quarter
    Cost
    Grants
    Owner
    Patient Advocacy lead

    Smallest test

    Co-host one webinar.

    Why it works

    Offer grants and joint webinars on living with recurrent disease and finding trials, with a neutral trial-finder resource the groups control.

    Advocacy partners are trusted sources, and the help reaches caregivers who search for options.

    Risks and how to handle them

    • Independence concerns

      Groups control content.

    Evidence

    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
  • 13

    The patient page offers guides and education, but the 27 presentations are written for specialists. Plain-language summaries are an accepted publication practice.

    Medium impactMedium effort First result in 1 quarter Associate Director

    First action

    Pick three key publications.

    How to measure it

    Summary page views

    Now
    –
    Target
    1,000 a month
    By
    2 quarters

    Steps

    1. 1

      Pick papers

      Three key items.

      Associate Director, Global Scientific Communications 1 week

    2. 2

      Write

      Plain language.

      Associate Director, Global Scientific Communications 1 month

    3. 3

      Patient review

      Two advisers.

      Patient Advocacy lead 2 weeks

    4. 4

      MLR

      Review.

      Legal & Compliance (PMRC) 2 weeks

    5. 5

      Publish

      Patients page.

      Web and digital agency 1 day

    6. 6

      Repeat

      Each congress.

      Associate Director, Global Scientific Communications ongoing

    First result
    1 quarter
    Cost
    Writing time
    Owner
    Associate Director, Global Scientific Communications

    Smallest test

    Publish one summary.

    Why it works

    Write plain-language summaries for the key publications, reviewed by patient advisers, and link them from the Patients page.

    Caregivers research deeply after recurrence; clear summaries build trust.

    Risks and how to handle them

    • Implied claims

      Follow GPP2022 and MLR.

    Evidence

    • HiringAssociate Director, Global Scientific Communications (posted July 6, 2026, still open): runs the global publication plan (manuscripts, abstracts, posters and "digital publication extenders"), pulls the Scientific Communication Platform into all deliverables, and builds slide decks, FAQs and "interactive educational tools" for field medical teams, under GPP2022 and ICMJE rules.Source
    • Your websiteSitemap (80 URLs): 27 presentations and publications (ASCO 2023 to ASCO 2026, ESMO, SITC, a 2026 Journal of Clinical Oncology paper), each a separate page with a long title; 31 team pages; no HCP-specific section, no disease-awareness hub beyond the Patients page, and no news posts on the site (press releases live on ir.bicara.com).Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
  • 14

    The Brand Lead will run message testing, segmentation and customer journey research for academic and community practices. Competing EGFR-directed Phase 3 programs mean differentiation must be learned early.

    High impactMedium effort First result in 1 quarter Senior Director

    First action

    Recruit 30 oncologists through a research panel.

    How to measure it

    Validated HCP segments

    Now
    –
    Target
    4
    By
    1 quarter

    Steps

    1. 1

      Design

      Research guide.

      Senior Director, Brand Lead - US 2 weeks

    2. 2

      Recruit

      30 oncologists.

      Market Research 1 month

    3. 3

      Interview

      Journeys.

      Market Research 1 month

    4. 4

      Segment

      By site of care.

      Senior Director, Brand Lead - US 2 weeks

    5. 5

      Share

      With HCP and field teams.

      Senior Director, Brand Lead - US 1 week

    6. 6

      Refresh

      After data readouts.

      Senior Director, Brand Lead - US quarterly

    First result
    1 quarter
    Cost
    Research budget
    Owner
    Senior Director, Brand Lead US

    Smallest test

    Run ten interviews.

    Why it works

    Run journey interviews with 30 community and academic oncologists on HPV testing, first-line choices and referral, and segment by site of care.

    Launch messaging built on real journeys avoids an expensive repositioning later.

    Risks and how to handle them

    • Small samples

      Mix interviews and a survey.

    Evidence

    • HiringSenior Director, Brand Lead - US (posted September 25, 2026): the "day-to-day brand owner" who builds the integrated brand plan "across HCP, patient, digital, field, and other customer channels", leads message testing, segmentation and customer journey research, "Day 0 planning", and engagement for "medical oncologists, academic and community oncology practices".Source
    • Competitor researchOther first-line R/M HNSCC Phase 3 programs on ClinicalTrials.gov: Merus's LiGeR-HN1 (petosemtamab plus pembrolizumab vs pembrolizumab, NCT06525220, active, not recruiting) and Janssen's OrigAMI-5 (amivantamab added to carboplatin and pembrolizumab, NCT07276399, recruiting). Both are EGFR-directed approaches in the same setting.Source
    • HiringDirector, HCP Marketing (Boston, posted October 16, 2026): leads HCP marketing strategy for ficerafusp alfa "as Bicara prepares for potential US FDA approval"; develops "the HCP launch plan across key channels, including personal promotion, digital/media marketing, peer-to-peer promotions, and congress"; oversees "omnichannel digital and media strategy"; part of "the launch readiness team".Source
  • 15

    The HCP role covers congress and the marketing operations role owns the commercial congress calendar. Bicara presents at ASCO, ESMO, SITC and head and neck meetings, but its site has no congress pages.

    High impactMedium effort First result in 1 quarter Director

    First action

    Build the template for the next major congress.

    How to measure it

    Requests per congress

    Now
    –
    Target
    200
    By
    2 quarters

    Steps

    1. 1

      Template

      Congress page.

      Web and digital agency 2 weeks

    2. 2

      Materials

      Posters and sessions.

      Associate Director, Global Scientific Communications per congress

    3. 3

      Form

      Medical information request.

      Head of Medical Affairs 2 weeks

    4. 4

      Follow-up

      MSLs respond.

      Senior Medical Science Liaison per congress

    5. 5

      Calendar

      All congresses.

      Director, Marketing Operations ongoing

    6. 6

      Measure

      Requests and meetings.

      Director, Marketing Operations per congress

    First result
    1 quarter
    Cost
    Agency time
    Owner
    Director, HCP Marketing

    Smallest test

    Pilot at the next head and neck meeting.

    Why it works

    For each major congress, publish a medical-affairs page with posters, sessions and a request-for-information form, and follow up with interested HCPs.

    Congresses are where specialists form views; a follow-up path captures that interest.

    Risks and how to handle them

    • Promotional drift

      Medical affairs owns the page.

    Evidence

    • HiringDirector, HCP Marketing (Boston, posted October 16, 2026): leads HCP marketing strategy for ficerafusp alfa "as Bicara prepares for potential US FDA approval"; develops "the HCP launch plan across key channels, including personal promotion, digital/media marketing, peer-to-peer promotions, and congress"; oversees "omnichannel digital and media strategy"; part of "the launch readiness team".Source
    • HiringDirector, Marketing Operations (posted August 21, 2026): will "Build the marketing operations function from the ground up", chair the Promotional Medical Review Committee (PMRC), set up MLR workflows and KPIs, own the commercial congress calendar, and "Ensure approved content is appropriately deployed, version-controlled, tracked, and retired across channels", including "email marketing, digital advertising, HCP websites, virtual programs".Source
    • Your websiteSitemap (80 URLs): 27 presentations and publications (ASCO 2023 to ASCO 2026, ESMO, SITC, a 2026 Journal of Clinical Oncology paper), each a separate page with a long title; 31 team pages; no HCP-specific section, no disease-awareness hub beyond the Patients page, and no news posts on the site (press releases live on ir.bicara.com).Source
  • 16

    bicara.com has no news posts; press releases are on ir.bicara.com. HCPs, candidates and patients visiting the main site see no recent news, while the company is moving toward commercial stage.

    Medium impactLow effort First result in 1 quarter Investor Relations

    First action

    Add the latest three releases to the homepage.

    How to measure it

    News page visits

    Now
    –
    Target
    +50%
    By
    2 quarters

    Steps

    1. 1

      Feed

      From IR releases.

      Web and digital agency 2 weeks

    2. 2

      Homepage

      Latest three.

      Web and digital agency 1 week

    3. 3

      Signup

      Email alerts.

      Investor Relations 1 week

    4. 4

      Review

      Disclosure check.

      Legal 1 week

    5. 5

      Publish

      Feed live.

      Web and digital agency 1 day

    6. 6

      Measure

      Visits and signups.

      Investor Relations monthly

    First result
    1 quarter
    Cost
    Agency time
    Owner
    Investor Relations

    Smallest test

    Link the latest release from the homepage.

    Why it works

    Add a news feed from the IR releases to the homepage and News page, and an email signup for updates.

    Visible momentum helps recruiting, partnerships and investor interest.

    Risks and how to handle them

    • Disclosure timing

      Feed only after IR publication.

    Evidence

    • Your websiteSitemap (80 URLs): 27 presentations and publications (ASCO 2023 to ASCO 2026, ESMO, SITC, a 2026 Journal of Clinical Oncology paper), each a separate page with a long title; 31 team pages; no HCP-specific section, no disease-awareness hub beyond the Patients page, and no news posts on the site (press releases live on ir.bicara.com).Source
    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
    • Your websiteCareers page: values ("Patient Driven, Highly Adaptive, Openly Candid") and a warning that "All formal communication regarding job opportunities at Bicara will come exclusively from an official @bicara.com email address"; the About page announces leadership transitions effective January 1, 2027.Source

Big bets 3

Larger plays that can change the trajectory.

  • 17

    The CCO, HCP marketing, Brand Lead and marketing operations hires are building launch readiness, and cash runs into 2029. CRM, consent, content and analytics systems take longer to build than campaigns.

    High impactHigh effort First result in 3 quarters Chief Commercial Officer

    First action

    Write requirements for the stack.

    How to measure it

    Systems live and tested

    Now
    –
    Target
    100%
    By
    3 quarters

    Steps

    1. 1

      Requirements

      Field, HCP, patient.

      Director, Marketing Operations 1 month

    2. 2

      Select

      Vendors.

      Director, Marketing Operations 1 quarter

    3. 3

      Implement

      CRM and consent.

      Commercial Operations 1 quarter

    4. 4

      Connect

      Content approval.

      Director, Marketing Operations 1 quarter

    5. 5

      Test

      Dry-run campaign.

      Director, HCP Marketing 1 month

    6. 6

      Train

      Field and marketing.

      Sales Training 1 month

    First result
    3 quarters
    Cost
    Platform licences
    Owner
    Chief Commercial Officer

    Smallest test

    Run one disease-hub email to opted-in HCPs.

    Why it works

    Select and implement CRM, consent management, content approval and analytics as one stack, with HCP consent captured from the disease hub and congress pages.

    A ready stack means launch-day campaigns run on real audiences.

    Risks and how to handle them

    • Built before needs are clear

      Phase it.

    Evidence

    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
    • HiringDirector, Marketing Operations (posted August 21, 2026): will "Build the marketing operations function from the ground up", chair the Promotional Medical Review Committee (PMRC), set up MLR workflows and KPIs, own the commercial congress calendar, and "Ensure approved content is appropriately deployed, version-controlled, tracked, and retired across channels", including "email marketing, digital advertising, HCP websites, virtual programs".Source
    • HiringDirector, HCP Marketing (Boston, posted October 16, 2026): leads HCP marketing strategy for ficerafusp alfa "as Bicara prepares for potential US FDA approval"; develops "the HCP launch plan across key channels, including personal promotion, digital/media marketing, peer-to-peer promotions, and congress"; oversees "omnichannel digital and media strategy"; part of "the launch readiness team".Source
    • HiringSenior Director, Brand Lead - US (posted September 25, 2026): the "day-to-day brand owner" who builds the integrated brand plan "across HCP, patient, digital, field, and other customer channels", leads message testing, segmentation and customer journey research, "Day 0 planning", and engagement for "medical oncologists, academic and community oncology practices".Source
  • 18

    The Brand Lead's plan spans patient strategy and partners with Patient Services. Bicara's caregiver guide shows its focus on families. Patient support quality drives starts and persistence after launch.

    High impactHigh effort First result in 4 quarters Patient Services lead

    First action

    Interview ten trial site nurses.

    How to measure it

    Service blueprint

    Now
    –
    Target
    Approved
    By
    4 quarters

    Steps

    1. 1

      Interviews

      Nurses and caregivers.

      Patient Advocacy lead 1 quarter

    2. 2

      Map barriers

      By journey stage.

      Senior Director, Brand Lead - US 1 month

    3. 3

      Design

      Hub services.

      Patient Services lead 1 quarter

    4. 4

      Vendors

      Hub partner.

      Patient Services lead 1 quarter

    5. 5

      Compliance

      Review.

      Legal & Compliance (PMRC) 1 month

    6. 6

      Ready

      At launch.

      Chief Commercial Officer 1 quarter

    First result
    4 quarters
    Cost
    Research and vendor fees
    Owner
    Patient Services lead

    Smallest test

    Interview five caregivers through an advocacy group.

    Why it works

    Run research with caregivers and trial site nurses on practical barriers (travel, nutrition, swallowing, cost) and design hub services from it.

    Services built from lived barriers support access at launch.

    Risks and how to handle them

    • Pre-approval limits

      Research only until approval.

    Evidence

    • HiringSenior Director, Brand Lead - US (posted September 25, 2026): the "day-to-day brand owner" who builds the integrated brand plan "across HCP, patient, digital, field, and other customer channels", leads message testing, segmentation and customer journey research, "Day 0 planning", and engagement for "medical oncologists, academic and community oncology practices".Source
    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source
    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
  • 19

    Bicara explores CRC, cutaneous SCC and other tumors. A consistent scientific platform pulled through all deliverables is what the scientific communications role is hired for.

    Medium impactHigh effort First result in 3 quarters Associate Director

    First action

    Audit current decks for message consistency.

    How to measure it

    MSL resource use

    Now
    –
    Target
    80% of meetings
    By
    3 quarters

    Steps

    1. 1

      Audit

      Decks and posters.

      Associate Director, Global Scientific Communications 1 month

    2. 2

      Platform

      Lexicon.

      Associate Director, Global Scientific Communications 1 month

    3. 3

      Build

      Resources.

      Associate Director, Global Scientific Communications 1 quarter

    4. 4

      Train

      MSLs.

      Head of Medical Affairs 1 month

    5. 5

      Update

      Each release.

      Associate Director, Global Scientific Communications ongoing

    6. 6

      Measure

      Use and feedback.

      Head of Medical Affairs quarterly

    First result
    3 quarters
    Cost
    Agency fees
    Owner
    Associate Director, Global Scientific Communications

    Smallest test

    Update one deck.

    Why it works

    Build a mechanism-focused scientific exchange resource (animations, slides, FAQs) for MSLs that is consistent across tumors and updated with each data release.

    Consistent science builds credibility across indications.

    Risks and how to handle them

    • Overreach

      Strict scientific exchange rules.

    Evidence

    • HiringAssociate Director, Global Scientific Communications (posted July 6, 2026, still open): runs the global publication plan (manuscripts, abstracts, posters and "digital publication extenders"), pulls the Scientific Communication Platform into all deliverables, and builds slide decks, FAQs and "interactive educational tools" for field medical teams, under GPP2022 and ICMJE rules.Source
    • Your websiteSitemap (80 URLs): 27 presentations and publications (ASCO 2023 to ASCO 2026, ESMO, SITC, a 2026 Journal of Clinical Oncology paper), each a separate page with a long title; 31 team pages; no HCP-specific section, no disease-awareness hub beyond the Patients page, and no news posts on the site (press releases live on ir.bicara.com).Source
    • HiringSenior Medical Science Liaison - West (CA, WA), posted August 17, 2026: "fair and balanced education on investigational products", relationships with investigators and institutions, the investigator-initiated research program, and "responses to unsolicited requests for medical information"; plus a Senior Clinical Trial Manager (posted September 17, 2026).Source

Wildcards 3

Unexpected experiments, each with a cheap way to test it.

  • 20

    ClinicalTrials.gov, the trial site, bicara.com and third-party trial finders each carry contact details. Inconsistent contacts confuse patients and the AI tools that summarize trials.

    Medium impactMedium effort First result in 1 quarter Senior Clinical Trial Manager

    First action

    Search for the trial on five trial-finder sites.

    How to measure it

    Correct listings

    Now
    –
    Target
    100%
    By
    1 quarter

    Steps

    1. 1

      Search

      Trial finders.

      Senior Clinical Trial Manager 1 week

    2. 2

      List

      Errors.

      Senior Clinical Trial Manager 1 week

    3. 3

      Fix

      Request corrections.

      Senior Clinical Trial Manager 1 month

    4. 4

      Structured data

      Trial page.

      Web and digital agency 1 week

    5. 5

      Check AI answers

      Common questions.

      Director, Marketing Operations monthly

    6. 6

      Repeat

      Quarterly.

      Senior Clinical Trial Manager quarterly

    First result
    1 quarter
    Cost
    $0
    Owner
    Senior Clinical Trial Manager

    Smallest test

    Fix the trial site contact first.

    Why it works

    Audit every listing of FORTIFI-HN01 and FLEX (registry, trial-finder sites, center pages) and align contacts and links; add structured data to the trial page.

    Consistency helps patients and referring doctors reach the right team.

    Risks and how to handle them

    • Third parties slow

      Prioritize the biggest finders.

    Evidence

    • Trial websitefortificlinicaltrial.com, the FORTIFI-HN01 recruitment site linked from bicara.com/patients, checked twice on October 22, 2026: the "Get in touch" block in the menu panel (the menu shown on tablets and phones) reads "555-555-5555" and "[email removed]", which are website-template placeholders. The page lists 49 US study centers in 25 states, says "For US audiences only", has no patient or clinician referral form, and does not mention the FORTIFI-FLEX study.Source
    • ClinicalTrials.govNCT06788990 (FORTIFI-HN01) is RECRUITING, estimated enrollment 650, record updated October 2, 2026, with 231 listed sites (55 in the US, 20 in Brazil, 18 in Italy, 15 each in Germany and the UK, sites in 28 countries). Central contact: Medical Affairs, 1-617-468-4219, [email protected]. FORTIFI-FLEX (NCT07807163, estimated 160) is also RECRUITING, record updated October 13, 2026.Source
    • Your websitebicara.com is a WordPress site whose page text is delivered inside a script variable and drawn by JavaScript: a plain fetch of /patients/ or /science/ returns only the menu words as page text. The Expanded Access Policy page reuses the homepage meta description. Seven job pages from January to March 2025 (/position/...) are still live and listed in the sitemap, while current roles are on the Ashby board.Source
  • 21

    Bicara is hiring a commercial team for a potential first launch, and leadership changes take effect January 1, 2027. Commercial candidates want to know the plan and team.

    Medium impactLow effort First result in 1 quarter Talent Acquisition

    First action

    Draft a commercial team page.

    How to measure it

    Qualified applicants per role

    Now
    –
    Target
    +30%
    By
    2 quarters

    Steps

    1. 1

      Draft

      Team story.

      Talent Acquisition 2 weeks

    2. 2

      Leader input

      CCO.

      Chief Commercial Officer 1 week

    3. 3

      Build

      Page.

      Web and digital agency 1 week

    4. 4

      Link roles

      Ashby.

      Talent Acquisition 1 day

    5. 5

      Promote

      LinkedIn.

      Talent Acquisition ongoing

    6. 6

      Measure

      Applicants.

      Talent Acquisition monthly

    First result
    1 quarter
    Cost
    Staff time
    Owner
    Talent Acquisition

    Smallest test

    Post one launch team video.

    Why it works

    Add a commercial careers page: launch team structure, leaders' backgrounds and what the first hires build, linking to Ashby roles.

    Experienced launch talent chooses companies with a clear plan.

    Risks and how to handle them

    • Forward-looking statements

      Legal review.

    Evidence

    • Your websiteCareers page: values ("Patient Driven, Highly Adaptive, Openly Candid") and a warning that "All formal communication regarding job opportunities at Bicara will come exclusively from an official @bicara.com email address"; the About page announces leadership transitions effective January 1, 2027.Source
    • Company updateQ1 2026 results (May 11, 2026): Bicara expects FORTIFI-HN01 to be "substantially enrolled by the end of the year" to enable an interim analysis in mid-2027 to support potential accelerated approval; cash, cash equivalents and marketable securities of $539.8 million fund operations "into the first half of 2029"; a Chief Commercial Officer was appointed to "lead the commercial organization in preparation for launch readiness"; the company is "rapidly evolving toward becoming a commercial-stage company".Source
    • HiringSenior Director, Brand Lead - US (posted September 25, 2026): the "day-to-day brand owner" who builds the integrated brand plan "across HCP, patient, digital, field, and other customer channels", leads message testing, segmentation and customer journey research, "Day 0 planning", and engagement for "medical oncologists, academic and community oncology practices".Source
  • 22

    The Patient Resource and Caregiver guides are PDFs on the Patients page. They are the kind of resource nurses and advocates share.

    Medium impactLow effort First result in 1 month Web and digital agency

    First action

    Create a page for the caregiver guide.

    How to measure it

    Downloads

    Now
    –
    Target
    +100%
    By
    2 quarters

    Steps

    1. 1

      Pages

      One per guide.

      Web and digital agency 1 week

    2. 2

      Print

      Printed copies.

      Patient Advocacy lead 1 month

    3. 3

      Spanish

      Translation.

      Patient Advocacy lead 1 month

    4. 4

      Share

      With nurses.

      Clinical Operations lead ongoing

    5. 5

      MLR

      Review.

      Legal & Compliance (PMRC) 2 weeks

    6. 6

      Measure

      Downloads.

      Director, Marketing Operations monthly

    First result
    1 month
    Cost
    Print and translation
    Owner
    Web and digital agency

    Smallest test

    Send the PDFs to five site nurses.

    Why it works

    Give each guide its own page with a short summary, print-friendly versions and Spanish editions, and give site nurses a printed version.

    Shareable resources extend reach to families.

    Risks and how to handle them

    • Outdated guides

      Review yearly.

    Evidence

    • Your websitePatients page: a patient quote, downloadable Patient Resource and Caregiver guides, descriptions of FORTIFI-HN01, FORTIFI-FLEX and the Phase 1b study, a Patient Education Center on HNSCC (an estimated 80% of R/M HNSCC cases are HPV-negative) and links to ClinicalTrials.gov and the trial site. The Expanded Access page says Bicara "does not currently offer" expanded access and gives a contact address for healthcare providers.Source

03

How Programmable can help

Where an idea in this playbook is something Programmable builds or runs, it's listed here with what we'd do. Everything else is yours to run.

ProgrammableTalk

Fill the events in this plan

These ideas are events. Talk gets registrants for them and tells you who's coming and what their company does before the day.

Plan an event (opens programmable.talk in a new tab)
More example playbooks and reviews

More growth playbooks

Other companies we have researched, each read from what they are hiring for.

  • Bath & Body Works growth strategyA U.S. specialty retailer of body care, home fragrance (candles and Wallflowers), soaps and sanitizers under Bath & Body Works, White Barn…20 growth ideas
  • Weee! growth strategyAmerica's largest online Asian supermarket, with free next-day grocery delivery, a Latino store (MásGusto), a local marketplace for…21 growth ideas
  • Cyclaa growth strategyA pre-launch app for cyclists in New York: mobile mechanics who come to you, shop booking, a gear marketplace with digital bike passports…20 growth ideas
  • SupplyHouse.com growth strategyAn online distributor of plumbing, heating, HVAC and electrical supplies, with over 180,000 products, four US fulfillment centers, an app…23 growth ideas
  • FOSSA growth strategySoftware supply chain management: FOSSA scans code, containers, binaries and snippets for open-source licenses and vulnerabilities…21 growth ideas
  • Ploy growth strategyAn AI marketing platform built around the company website: Ploy Web builds, migrates and optimizes marketing sites, Ploy Grow identifies…22 growth ideas
  • FarmGPU growth strategyA neocloud running NVIDIA H100, H200, B200 and B300 clusters with its own software (TractorOS, Shepherd, Haystack, Silo, Homestead), sold…22 growth ideas
  • Sol de Janeiro growth strategyA Brazilian-inspired body care and fragrance brand: Brazilian Bum Bum Cream, Cheirosa perfume mists, jelly balms, hair care, candles and…21 growth ideas

See every playbook and website review

Independent research. Programmable wrote this playbook from public sources, as they stood on October 23, 2026, and cites them throughout. Bicara Therapeutics did not commission, review or endorse it, and Programmable is not affiliated with Bicara Therapeutics. Company and product names are trademarks of their owners, used only to identify them. The ideas are suggestions and opinion, not professional, legal or financial advice, and not statements about how Bicara Therapeutics runs its business.

Something wrong, or do you represent Bicara Therapeutics? Email [email protected] and we will correct it or take it down.

30/60/90 roadmap

What to focus on in each month, and the ideas that carry it.

  1. Days 1 to 306 ideas

    Trial-site contact fix, Spanish snippet, FLEX section, server-rendered pages, hero image and old job pages.

  2. Days 31 to 6012 ideas

    Community referrals, publication library, disease hub, PMRC register, country pages, advocacy, summaries, journey research, congress playbook and news feed; align listings and guides.

  3. Days 61 to 904 ideas

    Launch stack, patient services design, scientific narrative and the commercial careers story.

The research behind the plan

3 research areas, each summarised in a few lines. Open any of them for the full detail.

Customers

What customers say

Customers value clear trial information and no-cost study treatment and tests. The most cited problem: finding a trial nearby.

  • Practical guides for patients and caregivers
  • Not knowing whom to call
  • In their words: “head and neck cancer”

Market

Competitive landscape

3 competitors compared: Merus (petosemtamab), Janssen (amivantamab) and Pembrolizumab standard of care.

  • Gap to exploit: Recruitment sites that route patients to a real contact
  • Merus (petosemtamab): Different mechanism, same setting
  • Janssen (amivantamab): Combination with chemotherapy

Hiring signals

Bicara is building a commercial team for a potential first US launch: a Director of HCP Marketing for the launch plan and omnichannel digital (ideas 3, 9, 15), a Director of Marketing Operations to build MLR/PMRC, the…

  • Director, HCP Marketing: HCP launch plan and omnichannel digital. Ideas 3, 9, 15.
  • Director, Marketing Operations: PMRC, version control and HCP websites. Ideas 1, 10, 17.
  • Senior Director, Brand Lead - US: Brand plan, message testing and segmentation. Ideas 14, 18.

From the team that wrote this playbook

All products
  • ProgrammableAgencyWorking AI systems in days, not quarters (opens programmable.agency in a new tab)
  • ProgrammableInfoAn agent that finds, researches and asks first (opens programmable.info in a new tab)
  • ProgrammableDigitalScreenshots in, an animated product demo out (opens programmable.digital in a new tab)
  • ProgrammableWatchKnow the day a supplier falls out of compliance (opens programmable.watch in a new tab)
  • ProgrammableTalkGet registrants for your events, and know who’s coming (opens programmable.talk in a new tab)
  • ProgrammablePageText what you need, your customer gets a page that works (opens programmable.page in a new tab)
  • ProgrammableCommunityForums with labelled AI members, never empty (opens programmable.community in a new tab)
ProgrammableMarketing
ExamplesLeaderboardsProductsTermsPrivacyCookiesDPALegalContact

© 2026 AI-Powered Growth Intelligence